Ignite Creation Date:
2024-05-06 @ 7:10 AM
Last Modification Date:
2024-10-26 @ 11:45 AM
Study NCT ID:
NCT02484521
Status:
COMPLETED
Last Update Posted:
2020-02-13
First Post:
2015-06-13
Brief Title:
Prepulse Inhibition PPI of Startle Reflex in Schizophrenia Patients Related to Type of Treatment and Illness Duration
Sponsor:
HaEmek Medical Center Israel
Organization:
HaEmek Medical Center Israel
Study Overview
Official Title:
Characteristics of Prepulse Inhibition PPI of Startle Reflex in Patients With Schizophrenia in Relation to Type of Pharmacological Treatment and Duration of Illness
Status:
COMPLETED
Status Verified Date:
2017-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
PPI is an objective measure to assess pre-attentive processes that have already been tested before in the case of schizophrenia The investigators aim to assess through this instrument two main characteristics that the investigators assume are of relevance which are the duration of illness and the type of pharmaceutical treatment patients receive
The investigators believe these two main characteristics are critical to the ability of the patients in improvement of their PPI response to startle reflex
The investigators believe these two main characteristics are critical to the ability of the patients in improvement of their PPI response to startle reflex
Detailed Description:
It is common to relate changes of PPI to startle reflex to both negative and positive signs of schizophrenia Results can both start to explain formations of delusions and hallucinations and the difficulty in processing information for surrounding It was already tested and discussed in previous trials the relation between type of pharmaceutical treatment as affecting on PPI to startle reflex both causing changes or improving previous results
In previous trials as opposed to our planned trial not much attention was paid for the relation on the changes found to the type of treatment and the duration of the illness Plus most trails had different methods of assessing it than our method
The investigators assume that patients who are receiving typical antipsychotic treatment would have a reduced PPI response to startle reflex compared with those with atypical antipsychotic treatment and those with longer duration of illness would also have reduced PPI response to startle reflex in comparison to those with shorted duration of illness
The investigators aim to enroll patients already diagnosed with schizophrenia that would be sent by their psychiatrist to the trial In addition the investigators would enroll control group not diagnosed with any psychiatric condition
For both groups the investigators would run PPI trials according to a unified protocol
In addition the investigators would run several questionnaires for the group of the patients Among the details asked of the patient are the duration of the illness and the type of antipsychotic medications they are on and the dosage Data will then be analyzed
In previous trials as opposed to our planned trial not much attention was paid for the relation on the changes found to the type of treatment and the duration of the illness Plus most trails had different methods of assessing it than our method
The investigators assume that patients who are receiving typical antipsychotic treatment would have a reduced PPI response to startle reflex compared with those with atypical antipsychotic treatment and those with longer duration of illness would also have reduced PPI response to startle reflex in comparison to those with shorted duration of illness
The investigators aim to enroll patients already diagnosed with schizophrenia that would be sent by their psychiatrist to the trial In addition the investigators would enroll control group not diagnosed with any psychiatric condition
For both groups the investigators would run PPI trials according to a unified protocol
In addition the investigators would run several questionnaires for the group of the patients Among the details asked of the patient are the duration of the illness and the type of antipsychotic medications they are on and the dosage Data will then be analyzed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None