Ignite Creation Date:
2024-05-05 @ 10:22 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00008749
Status:
UNKNOWN
Last Update Posted:
2005-06-24
First Post:
2001-01-16
Brief Title:
Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
Status:
UNKNOWN
Status Verified Date:
2003-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2000 women in the United States Recently several research laboratories have reported that a protein named CD40-ligand CD154 is overexpressed by a subset of white blood cells called lymphocytes in patients with lupus Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression
Detailed Description:
None
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: