Ignite Creation Date:
2024-05-05 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00197470
Status:
UNKNOWN
Last Update Posted:
2005-09-20
First Post:
2005-09-12
Brief Title:
Cytokine Gene Polymorphisms in Gastric Diseases
Sponsor:
Hamamatsu University
Organization:
Hamamatsu University
Study Overview
Official Title:
Effects of Pro-Inflammatory and Anti-Inflammatory Cytokine Gene Polymorphism on the Development of Gastric Cancer and Peptic Ulcer in Japanese
Status:
UNKNOWN
Status Verified Date:
2005-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Recently cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer We intended to clarify the association between polymorphisms of pro-inflammatory and anti-inflammatory cytokines and the susceptibility to gastric cancer gastric ulcer and duodenal ulcer in Japan and to detect the individuals who have higher risks for gastrointestinal disease development
Detailed Description:
H pylori infection has close associations with the development of peptic ulcer diseases as well as gastric cancer gastric adenoma and gastric MALT lymphoma The association of the host genetics with the susceptibility to various gastroduodenal disorders has been intensively investigated in the pathogenesis of peptic ulcer and gastric cancer by H pylori infection
In chronic active gastritis induced by H pylori infection activated neutrophils and mononuclear cells produce several pro-inflammatory and anti-inflammatory cytokines In fact levels of pro-inflammatory and anti-inflammatory cytokines are elevated in gastric mucosa infected with H pylori
Cytokine polymorphisms are associated with various inflammatory and autoimmune diseases Recently cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer However the roles of the IL-10 polymorphisms on the pathogenesis of H pylori-related gastric cancer and peptic ulcer have not been fully elucidatedIt is unclear whether pro-inflammatory and anti-inflammatory cytokines polymorphisms were associated with pathogenesis of peptic ulcer and gastric cancer in Japan Then we intended to clarify the association between polymorphisms of IL-10 and the susceptibility to gastric cancer gastric ulcer and duodenal ulcer in Japan and to detect the individuals who have higher risks for gastrointestinal disease development
In chronic active gastritis induced by H pylori infection activated neutrophils and mononuclear cells produce several pro-inflammatory and anti-inflammatory cytokines In fact levels of pro-inflammatory and anti-inflammatory cytokines are elevated in gastric mucosa infected with H pylori
Cytokine polymorphisms are associated with various inflammatory and autoimmune diseases Recently cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer However the roles of the IL-10 polymorphisms on the pathogenesis of H pylori-related gastric cancer and peptic ulcer have not been fully elucidatedIt is unclear whether pro-inflammatory and anti-inflammatory cytokines polymorphisms were associated with pathogenesis of peptic ulcer and gastric cancer in Japan Then we intended to clarify the association between polymorphisms of IL-10 and the susceptibility to gastric cancer gastric ulcer and duodenal ulcer in Japan and to detect the individuals who have higher risks for gastrointestinal disease development
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None