Ignite Creation Date:
2024-05-06 @ 4:04 AM
Last Modification Date:
2024-10-26 @ 11:43 AM
Study NCT ID:
NCT02441855
Status:
COMPLETED
Last Update Posted:
2015-06-04
First Post:
2015-05-08
Brief Title:
Potential Role for Echocardiography in Adult Patients With Community-Acquired Pneumonia
Sponsor:
Muğla Sıtkı Koçman University
Organization:
Muğla Sıtkı Koçman University
Study Overview
Official Title:
Is There a Potential Role for Echocardiography in Adult Patients With Community-Acquired Pneumonia Who Require Hospitalization A Pilot Study
Status:
COMPLETED
Status Verified Date:
2015-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Despite the efficacy of modern treatment community-acquired pneumonia CAP is the the leading cause of death Prognostic scores have been developed to estimate the risk of adverse outcome Several serum biomarkers have been also investigated in patients with CAP A growing number of echocardiographic markers have been evaluated as possible predictors of prognosis in patients with pulmonary and infectious diseases such as sepsis septic shock human immunodeficiency virus infection pulmonary tuberculosis and chronic obstructive pulmonary disease As echocardiography is a non-invasive reliable cost-effective and reproducible diagnostic tool to evaluate cardiac function and structures the investigators aimed to investigate left and right ventricular functions and aortic elastic properties in CAP patients Furthermore the investigators also aimed to observe relationships between echocardiographic findings and inflammatory and cardiac serum biomarkers in patients with CAP
Detailed Description:
Despite the efficacy of modern treatment community-acquired pneumonia CAP is the the leading cause of death Prognostic scores like the CURB-65 confusion urea respiratory rate arterial blood pressure and age score and the pneumonia severity index PSI have been developed and validated to estimate the risk of adverse outcome and to register a patient with CAP for hospital admission Serum biomarkers have been also investigated in patients with CAP like Procalcitonin and C-reactive protein Elevated N-terminal pro-brain natriuretic peptide NT-proBNP has been shown to be associated with adverse prognosis in several cardiac conditions and critically ill patients NT-proBNP is also shown to be important predictor in the emergency department and in hospitalized patients with CAP A growing number of echocardiographic markers have been evaluated as possible predictors of prognosis in patients with pulmonary and infectious diseases such as sepsis pulmonary tuberculosis and chronic obstructive pulmonary disease Although effects of pneumonia on cardiac structures is theoretically possible due to increased systemic inflammatory activity prothrombotic conditions biomechanical stress on coronary arteries variations in coronary arterial tone and altered myocardial metabolic balance during infections the role of transthoracic echocardiography has never been evaluated in patients with CAP As echocardiography is a non-invasive reliable cost-effective and reproducible diagnostic tool to evaluate cardiac function and structures the investigators aimed to investigate left and right ventricular functions and aortic elastic properties in CAP patients Furthermore the investigators also aimed to observe relationships between echocardiographic findings and inflammatory and cardiac serum biomarkers in patients with CAP
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None