Ignite Creation Date:
2024-05-05 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00198068
Status:
RECRUITING
Last Update Posted:
2024-04-08
First Post:
2005-09-12
Brief Title:
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus SLE and Antiphospholipid Syndrome APS
Sponsor:
Hospital for Special Surgery New York
Organization:
Hospital for Special Surgery New York
Study Overview
Official Title:
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus SLE and Antiphospholipid Syndrome APS
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PROMISSE
Brief Summary:
The PROMISSE Study is an observational study of 700 pregnant patients enrolled at nine major clinical centers The purpose of the study is 1 to determine whether certain proteins called complement split products that can injure healthy organs can be used to predict poor pregnancy outcome in patients with systemic lupus erythematosus SLE and anti-phospholipid syndrome APS andor 2 to determine whether elevated levels of circulating antiangiogenic factors predict pregnancy complications in patients with aPL antibodies andor SLE
Detailed Description:
Thrombosis and pregnancy loss are common features of systemic lupus erythematosus SLE particularly in the presence of antiphospholipid aPL antibodies The in vivo mechanisms by which aPL antibodies lead to vascular events and specifically to recurrent fetal loss are largely unknown Studies in a mouse model of antiphospholipid antibody syndrome APS indicate that in vivo complement activation is necessary for fetal loss caused by aPL antibodies This study represents an effort to translate these research observations on the potential role of complement activation in the pathogenesis of aPL antibody-mediated pregnancy loss to a clinically relevant human study
In addition studies in humans and mice have shown 1 that the balance of circulating angiogenic and antiangiogenic factors predicts preeclampsia and fetal growth restriction in healthy women 2 circulating antiangiogenic factors cause endothelial dysfunction and abnormal placental development in animal models and 3 complement activation leads to elevated levels of circulating antiangiogenic factors and complement inhibition prevents increased levels of antiangiogenic factors placental dysfunction and fetal growth restriction in a mouse model of APS This study will permit testing the hypothesis that like in healthy women the balance of circulating angiogenic and antiangiogenic factors predict complications in women with SLE and APS and to translate the findings in animal models into humans
The PROMISSE Study is a prospective observational study that will follow 700 pregnant patients who will be grouped and analyzed according to the presence or absence of aPL antibodies and preexisting SLE The patients are followed regularly during the course of the pregnancy collecting medical and obstetrical information as well as serial blood specimens for complement and cytokine assays The data obtained will be analyzed and used to identify mechanisms and predictors of poor fetal outcome We expect that the insights provided through this study will suggest means to prevent arrest or modify these conditions
In addition studies in humans and mice have shown 1 that the balance of circulating angiogenic and antiangiogenic factors predicts preeclampsia and fetal growth restriction in healthy women 2 circulating antiangiogenic factors cause endothelial dysfunction and abnormal placental development in animal models and 3 complement activation leads to elevated levels of circulating antiangiogenic factors and complement inhibition prevents increased levels of antiangiogenic factors placental dysfunction and fetal growth restriction in a mouse model of APS This study will permit testing the hypothesis that like in healthy women the balance of circulating angiogenic and antiangiogenic factors predict complications in women with SLE and APS and to translate the findings in animal models into humans
The PROMISSE Study is a prospective observational study that will follow 700 pregnant patients who will be grouped and analyzed according to the presence or absence of aPL antibodies and preexisting SLE The patients are followed regularly during the course of the pregnancy collecting medical and obstetrical information as well as serial blood specimens for complement and cytokine assays The data obtained will be analyzed and used to identify mechanisms and predictors of poor fetal outcome We expect that the insights provided through this study will suggest means to prevent arrest or modify these conditions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01AR049772 | NIH | None | httpsreporternihgovquickSearchR01AR049772 |