Ignite Creation Date:
2024-05-06 @ 3:58 AM
Last Modification Date:
2024-10-26 @ 11:42 AM
Study NCT ID:
NCT02427789
Status:
COMPLETED
Last Update Posted:
2015-04-29
First Post:
2014-01-24
Brief Title:
Therapeutic Effectiveness of Exercise Associated to the Pharmacotherapy in Major Depression
Sponsor:
University of Sao Paulo General Hospital
Organization:
University of Sao Paulo General Hospital
Study Overview
Official Title:
Therapeutic Effectiveness of Exercise Associated to the Pharmacotherapy in Major Depression
Status:
COMPLETED
Status Verified Date:
2013-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Depression is a disorder that causes major harm to physical health and social life It induces isolation reduced physical and work capacity and increasing the risk of death In contrast exercise helps to maintain quality of life also inducing improvement of cognitive functions stimulation of brain plasticity and resilience in addition to promoting self-esteem and social interaction The precise mechanisms by which exercise improves symptoms of depression are not fully clear but it is probably multifactorial In this project the investigators aim to investigate variables that provide additional information about biomarkers involved in the pathophysiology of depression and therapeutic response to exercise The investigators expect to find changes in biomarkers associated with potential mechanisms of neuroprotection cytokines markers of oxidative stress Brain-derived neurotrophic factor BDNF cortisol after exercise program and the role in the therapeutics of depression To evaluate functional assessment indices will be used ergospirometry a test that determines the respiratory cardiovascular and metabolic activity Overall this project will help to investigate alternative adjunctive treatments for depression and their associated biomarkers with response
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None