Ignite Creation Date:
2024-05-05 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00184886
Status:
COMPLETED
Last Update Posted:
2006-02-14
First Post:
2005-09-12
Brief Title:
The Influence of Methotrexate on the Metabolism and Vascular Effects of Adenosine in Humans
Sponsor:
Radboud University Medical Center
Organization:
Radboud University Medical Center
Study Overview
Official Title:
The Influence of Methotrexate on the Metabolism and Vascular Effects of Adenosine in Humans
Status:
COMPLETED
Status Verified Date:
2006-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study we aim to determine whether methotrexate influences the metabolism and vascular effects of adenosine in humans in vivo Adenosine is an endogenous purine-nucleoside with potent anti-inflammatory effects Also adenosine receptor stimulation induces vasodilation ischaemic preconditioning and many other cardiovacular effects Previous animal studies have provided limited evidence that the anti-inflammatory effects of methotrexate are mediated by adenosine receptor stimulation In this study we aim to determine whether also in humans in vivo methotretate influences endogenous adenosine Therefore 10 patients with inflammatory arthritis are treated with methotretxae 15 mgweek orally for 12 weeks Before and after treatment vasodilation to the infusion of adenosine and dipyridamole into the brachial artery is assessed as biomarker for the endogenous adenosine concentration
Also blood is drawn for the determination of CRP ESR Adenosine deaminase activity adn homocysteine
Also blood is drawn for the determination of CRP ESR Adenosine deaminase activity adn homocysteine
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| ZonMw Nr 920-03-249 | None | None | None |