Ignite Creation Date:
2024-05-06 @ 3:50 AM
Last Modification Date:
2024-10-26 @ 11:39 AM
Study NCT ID:
NCT02389595
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-05-17
First Post:
2015-03-10
Brief Title:
Selection of a Protective T Cell-based HIV-1FIV Vaccine
Sponsor:
University of Florida
Organization:
University of Florida
Study Overview
Official Title:
Selection of a Protective T Cell-based HIV-1FIV Vaccine Devoid of Viral Enhancing Epitopes
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research study is to develop a vaccine against Human immunodeficiency virus HIV a disease that causes AIDS in people The investigator will be looking at viruses similar to HIV in animals Since these viruses are very similar to HIV the blood from humans who have been exposed to HIV will be tested to see if the immune system will recognize the HIV and prevent infection
HIV targets the immune system by attacking certain T cells called CD4 T cells There are parts on the AIDS viruses that help the virus infect these cells and other parts that help the immune system prevent viral infection by activating protective T-cells that fight HIV Different T-cell populations are very important in most vaccines as they act as effectors that work as part of the immune system to recognize and fight off HIV infection When effector T cells are activated by appropriate protective parts of the virus they either block HIV from reproducing or kill HIV infected cells By finding these common protective parts of each of these human and animal AIDS viruses the investigator hopes to make a vaccine that helps the immune system prevent HIV infection by avoiding parts that attack CD4 T cells and may worsen HIV infection and selecting for parts that stimulate effector T cells that fight HIV infection
HIV targets the immune system by attacking certain T cells called CD4 T cells There are parts on the AIDS viruses that help the virus infect these cells and other parts that help the immune system prevent viral infection by activating protective T-cells that fight HIV Different T-cell populations are very important in most vaccines as they act as effectors that work as part of the immune system to recognize and fight off HIV infection When effector T cells are activated by appropriate protective parts of the virus they either block HIV from reproducing or kill HIV infected cells By finding these common protective parts of each of these human and animal AIDS viruses the investigator hopes to make a vaccine that helps the immune system prevent HIV infection by avoiding parts that attack CD4 T cells and may worsen HIV infection and selecting for parts that stimulate effector T cells that fight HIV infection
Detailed Description:
As a participant in this study a blood drawn will performed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5R01AI030904 | US NIH GrantContract | None | httpsreporternihgovquickSearch5R01AI030904 |