Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005356
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Novel Hemostatic Cardiac Risk Factors in Framingham
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate hemostatic variables in relation to cardiovascular risk in the Framingham Offspring Study cohort
Detailed Description:
BACKGROUND
Elevation of platelet reactivity plasminogen activator inhibitor fibrinogen von Willebrands factor and factor VII have been reported to increase myocardial infarction risk Myocardial infarction and sudden cardiac death are more frequent in the morning when platelet activity is increased and fibrinolysis is decreased Reduction of recurrent myocardial infarction by aspirin and coumadin suggests causal roles for platelet activity and coagulation Increases in viscosity and decreases in anti-thrombin III and Protein C have been linked with increased thrombosis Despite these findings a coherent picture of these disparate hemostatic indices as cardiac risk factors has yet to emerge
DESIGN NARRATIVE
Platelet reactivty plasminogen activatator inhibitor fibrinogen von Willebrands factor factor VII and other hemostatic risk factors were measured in all 4000 subjects of the Framingham Offspring Study The data were combined with the regularly collected Framingham data to determine the relationships between hemostatic factors and carotid atherosclerosis as assessed by ultrasound determine the relationship between hemostatic factors and the traditional cardiac risk factors and determine if hemostatic risk factors independently predict myocardial infarction and cardiac death
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Elevation of platelet reactivity plasminogen activator inhibitor fibrinogen von Willebrands factor and factor VII have been reported to increase myocardial infarction risk Myocardial infarction and sudden cardiac death are more frequent in the morning when platelet activity is increased and fibrinolysis is decreased Reduction of recurrent myocardial infarction by aspirin and coumadin suggests causal roles for platelet activity and coagulation Increases in viscosity and decreases in anti-thrombin III and Protein C have been linked with increased thrombosis Despite these findings a coherent picture of these disparate hemostatic indices as cardiac risk factors has yet to emerge
DESIGN NARRATIVE
Platelet reactivty plasminogen activatator inhibitor fibrinogen von Willebrands factor factor VII and other hemostatic risk factors were measured in all 4000 subjects of the Framingham Offspring Study The data were combined with the regularly collected Framingham data to determine the relationships between hemostatic factors and carotid atherosclerosis as assessed by ultrasound determine the relationship between hemostatic factors and the traditional cardiac risk factors and determine if hemostatic risk factors independently predict myocardial infarction and cardiac death
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL048157 | NIH | None | httpsreporternihgovquickSearchR01HL048157 |