Ignite Creation Date:
2024-05-06 @ 3:49 AM
Last Modification Date:
2024-10-26 @ 11:39 AM
Study NCT ID:
NCT02383524
Status:
UNKNOWN
Last Update Posted:
2015-03-11
First Post:
2015-03-04
Brief Title:
Genetic Predictors of Responsiveness to Radiofrequency Denervation in Chronic Low Back Pain
Sponsor:
Guys and St Thomas NHS Foundation Trust
Organization:
Guys and St Thomas NHS Foundation Trust
Study Overview
Official Title:
Does the Brain-derived Neurotrophic Factor Val66Met Gene Polymorphism Predict Inter-individual Variation in Responsiveness Following Lumbar Radiofrequency Denervation A Single-centre Prospective Exploratory Study in Subjects Diagnosed With Zygapophysial Joint Pain
Status:
UNKNOWN
Status Verified Date:
2015-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Investigators have designed this exploratory study in patients suffering from zygapophysial joint mediated pain to investigate if a correlation exists between inter-individual genetic variability genotype with treatment response phenotype More specifically the investigators aim to identify any form of correlation between a specific SNP of the BDNF gene Val66Met and the effectiveness andor duration of radiofrequency facet joint neurotomy The study population is patients suffering from chronic low back pain who have been scheduled for radiofrequency neurotomy following the diagnosis of facet joint mediated pain using medial branch block test The investigators will evaluate if a common variant of BDNF gene Val66Met can be directly correlated to a significant degree of pain relief following RF treatment and whether the result of such a procedure can be predicted from a specific genetic profile
Detailed Description:
Study Hypothesis It is possible to predict individual responsiveness to radiofrequency denervation for zygapophysial facet joint mediated pain on the basis of a specific genetic pattern Single Nucleotide Polymorphism SNP
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None