Ignite Creation Date:
2026-03-26 @ 3:20 PM
Ignite Modification Date:
2026-04-01 @ 2:18 AM
Study NCT ID:
NCT07402902
Status:
NOT_YET_RECRUITING
Last Update Posted:
2026-02-11
First Post:
2026-01-13
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Caffeine Strategies and Fat Oxidation
Sponsor:
Universidad Rey Juan Carlos
Organization:
Study Overview
Official Title:
Effects of Different Caffeine Ingestion Forms on Fat Oxidation During Cycle Ergometer Exercise
Status:
NOT_YET_RECRUITING
Status Verified Date:
2026-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to learn if different forms of caffeine ingestion can influence fat oxidation during submaximal cycling exercise. The study will recruit healthy adults, both men and women, aged 18 to 50, who regularly perform aerobic exercise. The main questions it aims to answer are:
* Does caffeine increase fat oxidation during one hour of cycling at the Fatmax intensity?
* Do different forms of caffeine ingestion (capsule, coffee, chewing gum, or mouth rinse) differ in their effect on fat oxidation?
* Do these caffeine forms alter total energy expenditure, cardiorespiratory response, or perceived exertion during exercise?
* Are there differences in the occurrence or severity of side effects between caffeine administration methods?
Researchers will compare each caffeine form to its corresponding placebo to determine their effects on fat oxidation and other physiological outcomes.
Participants will:
* Attend a pre-experimental session to determine their Fatmax intensity and VO₂max using an incremental cycling test
* Perform eight experimental sessions, each consisting of one hour of cycling at Fatmax intensity
* Receive caffeine or placebo via capsules, coffee, chewing gum, or mouth rinse according to a randomized, double-blind, crossover design
* Be monitored for fat and carbohydrate oxidation, total energy expenditure, heart rate, and perceived exertion during exercise
* Report any side effects immediately after the session and 24 hours later using a structured questionnaire
All sessions will be conducted under controlled laboratory conditions with standardized protocols to ensure safety and reliable measurements.
* Does caffeine increase fat oxidation during one hour of cycling at the Fatmax intensity?
* Do different forms of caffeine ingestion (capsule, coffee, chewing gum, or mouth rinse) differ in their effect on fat oxidation?
* Do these caffeine forms alter total energy expenditure, cardiorespiratory response, or perceived exertion during exercise?
* Are there differences in the occurrence or severity of side effects between caffeine administration methods?
Researchers will compare each caffeine form to its corresponding placebo to determine their effects on fat oxidation and other physiological outcomes.
Participants will:
* Attend a pre-experimental session to determine their Fatmax intensity and VO₂max using an incremental cycling test
* Perform eight experimental sessions, each consisting of one hour of cycling at Fatmax intensity
* Receive caffeine or placebo via capsules, coffee, chewing gum, or mouth rinse according to a randomized, double-blind, crossover design
* Be monitored for fat and carbohydrate oxidation, total energy expenditure, heart rate, and perceived exertion during exercise
* Report any side effects immediately after the session and 24 hours later using a structured questionnaire
All sessions will be conducted under controlled laboratory conditions with standardized protocols to ensure safety and reliable measurements.
Detailed Description:
None
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: