Ignite Creation Date:
2026-03-26 @ 3:19 PM
Ignite Modification Date:
2026-03-30 @ 2:53 AM
Study NCT ID:
NCT07440394
Status:
COMPLETED
Last Update Posted:
2026-02-27
First Post:
2025-07-27
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Evaluation of Pine Bark Extract for Anti-fatigue Ergogenic Properties
Sponsor:
China Medical University Hospital
Organization:
Study Overview
Official Title:
Evaluation of Pine Bark Extract for Anti-fatigue Ergogenic Properties
Status:
COMPLETED
Status Verified Date:
2026-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This research proposal aims to elucidate the physiological responses to pine bark extract supplementation during a single bout of high-intensity cycling exercise at 70% VO₂max and the subsequent recovery phase. Specifically, the study seeks to investigate the underlying mechanisms by which pine bark extract modulates exercise-induced fatigue and metabolic fitness, and to determine whether such supplementation may enhance endurance performance in the post-recovery period.
Detailed Description:
The primary active component of natural pine bark extract (PBE) is proanthocyanidins, which possess antioxidant, anti-inflammatory, and endothelial function-enhancing properties. These attributes suggest its potential as an ergogenic aid to improve exercise performance. In this study, 14 healthy participants will be randomly assigned to receive either 300 mg/day of PBE or a placebo for 4 consecutive days. Following supplementation, participants will consume a low-calorie meal (300 kcal) accompanied by either the placebo or PBE and rest for one hour. One hour after capsule ingestion, participants will perform a 60-minute cycling exercise at 70% VO₂max. Upon completion of the exercise challenge, they will consume a post-exercise meal adjusted to body weight. After a 3-hour recovery period, subjects will undergo an anaerobic power test followed by an endurance test at 75% VO₂max to volitional exhaustion. Gas exchange and blood samples will be collected at multiple time points: pre- and post-initial cycling session, during the recovery phase, and following the exhaustive endurance test. Gas samples will be analyzed to determine rates of fat and carbohydrate oxidation. Blood biomarkers will be assessed for glucose, superoxidase dismutase (SOD), malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), creatine kinase (CK), lactate dehydrogenase (LDH), and uric acid (UA).
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: