Ignite Creation Date:
2024-05-06 @ 3:48 AM
Last Modification Date:
2024-10-26 @ 11:38 AM
Study NCT ID:
NCT02372773
Status:
COMPLETED
Last Update Posted:
2020-08-03
First Post:
2015-02-20
Brief Title:
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
Status:
COMPLETED
Status Verified Date:
2020-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LEFFTDS
Brief Summary:
This study is being done to learn more about normal thinking and behavior mild thinking and behavior problems Frontotemporal Dementia and other forms of dementia in families in which one or more relatives have a mutation associated with Frontotemporal Dementia
Detailed Description:
This multicenter study will enroll 300 members of familial Frontotemporal Dementia FTD families across 8 experienced FTD research centers with a known mutation in MAPT PGRN or C9ORF72 100 mutation carriers with mild dementia or minimally symptomatic yet non-demented 100 asymptomatic mutation carriers and 100 clinically normal relatives who are non-mutation carriers to obtain annual assessments including T1-MRI FLAIR diffusion tensor imaging DTI ASL perfusion ASLp intrinsic connectivity functional MRI icfMRI MR spectroscopy MRS CSF blood and behavioral neuropsychological and functional assessment for a total of three assessments per participant
A primary goal of this study is to identify the most robust and reliable methods to track disease progression in familial FTD so that disease-modifying therapeutic trials can be designed appropriately
A primary goal of this study is to identify the most robust and reliable methods to track disease progression in familial FTD so that disease-modifying therapeutic trials can be designed appropriately
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U01AG045390 | NIH | None | httpsreporternihgovquickSearchU01AG045390 |