Ignite Creation Date:
2024-05-05 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00184249
Status:
WITHDRAWN
Last Update Posted:
2015-03-20
First Post:
2005-09-13
Brief Title:
A Prospective Multi Centre Trial on Bipolar Radiofrequency Ablation of Atrial Fibrillation
Sponsor:
Norwegian University of Science and Technology
Organization:
Norwegian University of Science and Technology
Study Overview
Official Title:
A Prospective Multi Centre Trial on Bipolar Radiofrequency Ablation of Atrial Fibrillation
Status:
WITHDRAWN
Status Verified Date:
2015-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Collaborators did not enter patients into the study
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study is a prospective multi-centre study to investigate the effect of a new bipolar ablation strategy of the left atrium in patients with paroxysmal or permanent atrial fibrillation over time
Detailed Description:
Atrial fibrillation AF is the most common persistent arrhythmia prevalent in about 6 of the population over 65 years of age AF reduces the quality of life and increases mortality AF is particularly common in combination with mitral valve disease but is also detected in about 5 of patients with aortic valve and coronary artery disease Surgical treatment of AF with the Cox-maze III operation was developed by J Cox during the 80ies The aim of the operation is to block spread of irregular electrical activity by creating lines of isolation in the atrial musculature The operation achieves sinus rhythm in over 90 in selected patients Nevertheless the method was only used in few heart surgical centres because it is complex and time consumingIn recent years alternative energy sources have been developed to create isolating lines without cutting the tissue and thus making ablation treatment easier Bipolar radiofrequency ablation is special because the energy is delivered feedback controlled until transmurality is achieved This is a prerequisite for a good result and makes using the equipment safer
Since the development of the Cox-maze procedure our knowledge of atrial fibrillation and its treatment has increased considerably There is a consensus that the posterior part of the left atrium and in particular the pulmonary veins are an important target for treatment Surgical ablation with alternative energy sources is a new method under continued development and evaluation
The optimal ablation treatment is unknown A balance between invasiveness and achieving sinus rhythm in as many as possible has to be found Creating numerous ablation lines in both atria is time consuming and leads probably to an increased need for permanent pacemaker implantation and reduced contractility of the atrial tissue On the other hand can a simple bipolar ablation of pulmonary veins performed easily but this is probably an insufficient treatment for most patients In the protocol a new method using solely bipolar ablation for creation of several ablation lines in the left atrium is described
The study is a prospective multi-centre study to investigate the effect of a new bipolar ablation strategy of the left atrium in patients with paroxysmal or permanent AF over time
Since the development of the Cox-maze procedure our knowledge of atrial fibrillation and its treatment has increased considerably There is a consensus that the posterior part of the left atrium and in particular the pulmonary veins are an important target for treatment Surgical ablation with alternative energy sources is a new method under continued development and evaluation
The optimal ablation treatment is unknown A balance between invasiveness and achieving sinus rhythm in as many as possible has to be found Creating numerous ablation lines in both atria is time consuming and leads probably to an increased need for permanent pacemaker implantation and reduced contractility of the atrial tissue On the other hand can a simple bipolar ablation of pulmonary veins performed easily but this is probably an insufficient treatment for most patients In the protocol a new method using solely bipolar ablation for creation of several ablation lines in the left atrium is described
The study is a prospective multi-centre study to investigate the effect of a new bipolar ablation strategy of the left atrium in patients with paroxysmal or permanent AF over time
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None