Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00185731
Status:
COMPLETED
Last Update Posted:
2017-12-02
First Post:
2005-09-12
Brief Title:
Phase 2 Study of Atorvastatin Safety and Antitumor Effects in Non-Hodgkins Lymphoma
Sponsor:
Dean Felsher
Organization:
Stanford University
Study Overview
Official Title:
A Phase II Study of Atorvastatin in Patients With Low Grade or Refractory Non-Hodgkins Lymphoma
Status:
COMPLETED
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is an approach which can inflict significant toxicity An alternative is to block expression of oncogenes which are over-expressed only in cancer cells a therapeutic approach which could reduce toxicity to the host while maximizing destruction of the oncogene-dependent malignant cells
Detailed Description:
Atorvastatin has been shown to decrease levels of active oncogenes in preclinical studies with murine and human lymphoma cell lines and administration of statins leads to shrinkage of lymphoma in murine models Therefore it may be possible for atorvastatin to decrease levels of active oncogenes in human lymphomas Further upon decrease in levels of active oncogenes human lymphomas may regress Atorvastatin is a commonly prescribed drug for hypercholesterolemia targeting the 3-hydroxy-3-methylglutaryl-coenzyme A HMG-CoA reductase enzyme may also be a way to decrease activation of oncogenes in human lymphoma with minimal toxicity For human low grade non-Hodgkin lymphoma no curative treatment is available therefore new non-toxic and targeted therapies are sought for this disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| LYMNHL0020 | OTHER | OnCore | None |
| 4328-07 | OTHER | None | None |
| 95140 | OTHER | None | None |