Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00181545
Status:
COMPLETED
Last Update Posted:
2009-06-30
First Post:
2005-09-13
Brief Title:
Safety Study of Individualised Radiation Dose Determination for Lung Cancer Patients
Sponsor:
Maastricht Radiation Oncology
Organization:
Maastricht Radiation Oncology
Study Overview
Official Title:
Individualised Radiation Dose Determination on Basis of Normal Tissue Dose Constraints in Patients With Non-Small-Cell Lung Cancer A Phase I Study
Status:
COMPLETED
Status Verified Date:
2009-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Radiotherapy is treatment of choice for inoperable lung cancer Research has shown that the local control rate is low and the radiation often causes pneumonitis andor esophagitis
To predict to lung damage the mean lung dose can be calculated This allows us to give a higher total dose to the tumor and to improve the local control rate
Study hypothesis It will be safe to administer a radiation dose as high as possible to the tumor taking into account the mean lung dose calculated by the treatment planning system
To predict to lung damage the mean lung dose can be calculated This allows us to give a higher total dose to the tumor and to improve the local control rate
Study hypothesis It will be safe to administer a radiation dose as high as possible to the tumor taking into account the mean lung dose calculated by the treatment planning system
Detailed Description:
Radiotherapy is treatment of choice for inoperable lung cancer Research has shown that the survival rate as well as the local control rate is low If chemotherapy treatment is added it leads to a slightly better outcome The radiotherapy treatment often causes pneumonitis andor esophagitis So damage to the normal tissue restricts the radiation dose that can be administered
However several studies have shown that higher doses lead to better local control Furthermore it is evident that the radiotherapy treatment should be given in a short time preferably the treatment time should not exceed 32 days
To avoid a higher toxicity the normal tissue has to be spared but to increase the local control rate the tumor dose must be as high as possible This dilemma can only be solved by using very sophisticated treatment planning techniques in combination with a biologically superior treatment schedule This schedule consists of delivering radiation dose twice a day instead of once thus keeping the overall treatment time as low as possible
For the whole patient population the mean lung dose can to a great extend predict the probability for developing radiation pneumonitis and the post-radiotherapy lung function A logical next step is to determine the dose of radiotherapy on an individualised calculation of the maximum tolerated dose being defined as the mean lung dose and the spinal cord dose
The objective of this trial is to investigate whether individualised radiation dose calculation based on a mean lung dose and the constraints of the spinal cord in combination with an overall treatment time of less than 32 days and only irradiating the primary tumor and the PET scan positive mediastinal areas is safe
However several studies have shown that higher doses lead to better local control Furthermore it is evident that the radiotherapy treatment should be given in a short time preferably the treatment time should not exceed 32 days
To avoid a higher toxicity the normal tissue has to be spared but to increase the local control rate the tumor dose must be as high as possible This dilemma can only be solved by using very sophisticated treatment planning techniques in combination with a biologically superior treatment schedule This schedule consists of delivering radiation dose twice a day instead of once thus keeping the overall treatment time as low as possible
For the whole patient population the mean lung dose can to a great extend predict the probability for developing radiation pneumonitis and the post-radiotherapy lung function A logical next step is to determine the dose of radiotherapy on an individualised calculation of the maximum tolerated dose being defined as the mean lung dose and the spinal cord dose
The objective of this trial is to investigate whether individualised radiation dose calculation based on a mean lung dose and the constraints of the spinal cord in combination with an overall treatment time of less than 32 days and only irradiating the primary tumor and the PET scan positive mediastinal areas is safe
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| MAASTRO 04-06 | None | None | None |