Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00184912
Status:
COMPLETED
Last Update Posted:
2006-11-29
First Post:
2005-09-12
Brief Title:
The Effect of Caffeine on Ischemic Preconditioning
Sponsor:
Radboud University Medical Center
Organization:
Radboud University Medical Center
Study Overview
Official Title:
Caffeine Reduces Acute Ischemic Preconditioning
Status:
COMPLETED
Status Verified Date:
2006-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Ischaemic preconditioning IP describes the phenomenon that brief periods of ischaemia render the myocardial muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion Animal studies have provided evidence that adenosine receptor stimulation is an important mediator of IP As caffeine is an effective adenosine receptor antagonist already at concentrations reached after regular coffee consumption we aimed to assess whether caffeine impairs IP in humans in vivo We used a novel and well-validated model to study IP in humans 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle
24 healthy volunteers were randomly assigned to either caffeine 4 mgkgiv in 10 minutes or saline before a protocol for IP
24 healthy volunteers were randomly assigned to either caffeine 4 mgkgiv in 10 minutes or saline before a protocol for IP
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None