Ignite Creation Date:
2024-05-06 @ 3:43 AM
Last Modification Date:
2024-10-26 @ 11:37 AM
Study NCT ID:
NCT02351518
Status:
COMPLETED
Last Update Posted:
2022-01-27
First Post:
2015-01-19
Brief Title:
Cerebral Autoregulation and Vasospasm in Patients With TBI
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Cerebral Autoregulation and Vasospasm in Patients With Traumatic Brain Injury
Status:
COMPLETED
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Traumatic brain injury TBI affects 15 million patients per year in the United States resulting in more than 50000 deaths and more than 230000 hospitalizations annually Approximately 90000 of these patients will suffer permanent impairment and more than half will experience short-term disability
Secondary injury processes play a critical role in the development of ischemia after trauma to the central nervous system and occur hours-to-days after the primary insult Ischemia can lead to cerebral infarction or stroke Ischemia has been described as the single most important secondary insult and has been identified histologically in approximately 90 of patients who die following closed head injury Several factors resulting in post-traumatic cerebral ischemia have been identified increased intracranial pressure ICP systemic arterial hypotension and cerebral vasospasm Cerebral vasospasm has been described as a sustained arterial narrowing Clinically the onset of new or worsening neurological symptoms is the most reliable indicator of cerebral vasospasm following a ruptured cerebral aneurysm However cerebral vasospasm is often unrecognized in patients suffering from moderate to severe TBI These patients frequently have altered mental status due to the primary brain injury In addition they require narcotics for their pain and paralytics andor sedatives while on a mechanical ventilator for airway protection Thus relying on the neurological exam to observe deteriorating neurological signs consistent with post-traumatic vasospasm PTV is reliable While the etiology and outcome of patients with vasospasm secondary to ruptured aneurysm is well documented the clinical significance of PTV after TBI is unknown A better understanding of the role of cerebral autoregulation in the development of cerebral vasospasm could provide the answer This proposal is for a pilot observational study describing the association of the impairment of cerebral autoregulation as measured by near infrared spectroscopy NIRS with the development of clinically significant vasospasm in patients with moderate to severe TBI The information will serve as preliminary data for further study
Secondary injury processes play a critical role in the development of ischemia after trauma to the central nervous system and occur hours-to-days after the primary insult Ischemia can lead to cerebral infarction or stroke Ischemia has been described as the single most important secondary insult and has been identified histologically in approximately 90 of patients who die following closed head injury Several factors resulting in post-traumatic cerebral ischemia have been identified increased intracranial pressure ICP systemic arterial hypotension and cerebral vasospasm Cerebral vasospasm has been described as a sustained arterial narrowing Clinically the onset of new or worsening neurological symptoms is the most reliable indicator of cerebral vasospasm following a ruptured cerebral aneurysm However cerebral vasospasm is often unrecognized in patients suffering from moderate to severe TBI These patients frequently have altered mental status due to the primary brain injury In addition they require narcotics for their pain and paralytics andor sedatives while on a mechanical ventilator for airway protection Thus relying on the neurological exam to observe deteriorating neurological signs consistent with post-traumatic vasospasm PTV is reliable While the etiology and outcome of patients with vasospasm secondary to ruptured aneurysm is well documented the clinical significance of PTV after TBI is unknown A better understanding of the role of cerebral autoregulation in the development of cerebral vasospasm could provide the answer This proposal is for a pilot observational study describing the association of the impairment of cerebral autoregulation as measured by near infrared spectroscopy NIRS with the development of clinically significant vasospasm in patients with moderate to severe TBI The information will serve as preliminary data for further study
Detailed Description:
Primary Objectives 1 To determine if impaired cerebral autoregulation as measured by NIRS is associated with clinically significant vasospasm in patients with moderate to severe TBI 2 To determine the sensitivity and specificity of NIRS in detecting clinically significant vasospasm with Transcranial Doppler TCD ultrasound followed by CT brain angiography and diffusion-weighted brain MRI as the gold standard Secondary Objectives 1 To determine the relationship between impaired cerebral autoregulation and outcomes 2 To determine the relationship between impaired cerebral autoregulation clinically significant vasospasm and outcomes
Clinical observations The subject will be continuously monitored with INVOS NIRS system within the first 24 hours after admission up to 7 days while the subject is still in the STC If decreased cerebral oxygenation is detected by NIRS TCDs will be offered to the family and considered part of routine clinical care If vasospasm is detected by TCD CT brain angiography will be offered to the family for angiographic confirmation and considered part of routine clinical care If vasospasm is confirmed by CT brain angiography diffusion-weighted MRI will be offered to the family to evaluate for cerebral ischemiainfarction and considered part of routine clinical care
Laboratory evaluations All patients will have at least twice daily measurements of serum electrolytes blood counts arterial blood gases and coagulation profile as per our standard of care Culture results will be recorded No tests or procedure will be ordered for research purposes only
Patient Management All enrolled patients will be admitted to the Neurotrauma Critical Care Unit NTCC and be jointly managed by the Trauma Critical Care and Neurosurgical services All patients will be managed utilizing the STC Institutional Severe Traumatic Brain Injury Management Algorithm which is based on the Brain Trauma Foundation Guidelines for the Management of Severe Traumatic Brain Injury Other consults will be obtained as clinically indicated
Questionnaires Assessment tools Functional outcome using the Extended Glasgow Outcome Scale GOS-E will be assessed in the STC Outpatient Clinic as part of their standard of care An early functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic within 6 weeks post hospital discharge day A mid functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic 6 weeks to 3 months post hospital discharge day A late functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic 3 months to 6 months post hospital discharge day Finally a very late functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic more than 6 months post-hospital discharge day
STATISTICAL CONSIDERATIONS ANALYSIS OF DATA The goal of this pilot study is to determine if impaired cerebral autoregulation as measured by NIRS is associated with the development of clinically significant vasospasm in patients with moderate to severe TBI By enrolling 100 patients in the study it is expected to estimate the correlation to within 0098 with a probability of at least 95 In this study all primary and secondary outcomes may be classified into two categories binary and continuous In the first step quantitative descriptive statistics will be used initially to study the characteristics of patients and the association between clinical outcomes eg vasospasm and various demographic and clinicopathologic variables such as age gender and injury severity scores For binary data chi-square and Fishers exact tests will be used to identify differences For continuous variables t-tests and analysis of variance ANOVA will be used to determine the significant association These univariate tests will be done at a significance level of 005 In addition to constructing 95 confidence interval for the correlation of impaired cerebral autoregulation as measured by NIRS and clinically significant vasospasm the investigators will also explore potential risk factors associated with impaired cerebral autoregulation and impaired cerebral autoregulation associated with vasospasm To this end the correlation will be analyzed using the logistic regression model with various demographic and clinicopathologic variables as independent variables The stepwise regression procedure will be used for identifying potential risk factors for the incidence of vasospasm To evaluate the validity of NIRs as an assessment method of vasospasm the investigators will measure the agreement between TCD and NIRS by using kappa statistics
Clinical observations The subject will be continuously monitored with INVOS NIRS system within the first 24 hours after admission up to 7 days while the subject is still in the STC If decreased cerebral oxygenation is detected by NIRS TCDs will be offered to the family and considered part of routine clinical care If vasospasm is detected by TCD CT brain angiography will be offered to the family for angiographic confirmation and considered part of routine clinical care If vasospasm is confirmed by CT brain angiography diffusion-weighted MRI will be offered to the family to evaluate for cerebral ischemiainfarction and considered part of routine clinical care
Laboratory evaluations All patients will have at least twice daily measurements of serum electrolytes blood counts arterial blood gases and coagulation profile as per our standard of care Culture results will be recorded No tests or procedure will be ordered for research purposes only
Patient Management All enrolled patients will be admitted to the Neurotrauma Critical Care Unit NTCC and be jointly managed by the Trauma Critical Care and Neurosurgical services All patients will be managed utilizing the STC Institutional Severe Traumatic Brain Injury Management Algorithm which is based on the Brain Trauma Foundation Guidelines for the Management of Severe Traumatic Brain Injury Other consults will be obtained as clinically indicated
Questionnaires Assessment tools Functional outcome using the Extended Glasgow Outcome Scale GOS-E will be assessed in the STC Outpatient Clinic as part of their standard of care An early functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic within 6 weeks post hospital discharge day A mid functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic 6 weeks to 3 months post hospital discharge day A late functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic 3 months to 6 months post hospital discharge day Finally a very late functional outcome assessment will be obtained if the GOS-E form is completed at the STC Outpatient Clinic more than 6 months post-hospital discharge day
STATISTICAL CONSIDERATIONS ANALYSIS OF DATA The goal of this pilot study is to determine if impaired cerebral autoregulation as measured by NIRS is associated with the development of clinically significant vasospasm in patients with moderate to severe TBI By enrolling 100 patients in the study it is expected to estimate the correlation to within 0098 with a probability of at least 95 In this study all primary and secondary outcomes may be classified into two categories binary and continuous In the first step quantitative descriptive statistics will be used initially to study the characteristics of patients and the association between clinical outcomes eg vasospasm and various demographic and clinicopathologic variables such as age gender and injury severity scores For binary data chi-square and Fishers exact tests will be used to identify differences For continuous variables t-tests and analysis of variance ANOVA will be used to determine the significant association These univariate tests will be done at a significance level of 005 In addition to constructing 95 confidence interval for the correlation of impaired cerebral autoregulation as measured by NIRS and clinically significant vasospasm the investigators will also explore potential risk factors associated with impaired cerebral autoregulation and impaired cerebral autoregulation associated with vasospasm To this end the correlation will be analyzed using the logistic regression model with various demographic and clinicopathologic variables as independent variables The stepwise regression procedure will be used for identifying potential risk factors for the incidence of vasospasm To evaluate the validity of NIRs as an assessment method of vasospasm the investigators will measure the agreement between TCD and NIRS by using kappa statistics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None