Ignite Creation Date:
2024-05-06 @ 3:41 AM
Last Modification Date:
2024-10-26 @ 11:37 AM
Study NCT ID:
NCT02346123
Status:
COMPLETED
Last Update Posted:
2015-10-12
First Post:
2015-01-20
Brief Title:
Determination of Genetic Polymorphisms in Chronic Chagas Cardiomyopathy
Sponsor:
Hospital Sao Rafael
Organization:
Hospital Sao Rafael
Study Overview
Official Title:
Determination of Genetic Polymorphisms in Chronic Chagas Cardiomyopathy
Status:
COMPLETED
Status Verified Date:
2015-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to analyze the influence of polymorphisms of the genes CLDN-1 Claudina-1 LGALS3 Lectin galactoside-binding soluble 3 SOCS3 Suppressor of cytokine signaling 3 IL-28B interleukin-28B CCL5 Chemokine C-C ligand 5 in the determination of clinical forms and in the percentage of cardiac fibrosis in patients with Chagas disease
Detailed Description:
The Chagas disease in its chronic phase can lead to the development of cardiac arrhythmias and dilated cardiomyopathy which can evolve to heart failure causing great morbidity and reduction on patients quality of life Some patients stay asymptomatic while others develop the cardiac form of the disease chronic chagasic cardiomyopathy or other forms like the digestive megacolon and megaesophagus and the mixed form cardiac and digestive
The objective of this study is to analyze the association between single nucleotide polymorphisms with the clinical forms and the amount of cardiac fibrosis in patients with Chagas disease
The polymorphisms will be analyzed by real time PCR Polymerase Chain Reaction The genes whose polymorphisms will be analyzed are galectin-3 SOCS-3 IL-28B CLDN-1 and CCL5
The patients shall be accompanied in the specialized outpatient clinics for Chagas disease - Center of Biotechnology and Cell Therapy They will be submitted to collection of blood samples for biochemical analysis and cardiac magnetic resonance imaging
The objective of this study is to analyze the association between single nucleotide polymorphisms with the clinical forms and the amount of cardiac fibrosis in patients with Chagas disease
The polymorphisms will be analyzed by real time PCR Polymerase Chain Reaction The genes whose polymorphisms will be analyzed are galectin-3 SOCS-3 IL-28B CLDN-1 and CCL5
The patients shall be accompanied in the specialized outpatient clinics for Chagas disease - Center of Biotechnology and Cell Therapy They will be submitted to collection of blood samples for biochemical analysis and cardiac magnetic resonance imaging
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None