Ignite Creation Date:
2024-05-06 @ 3:40 AM
Last Modification Date:
2024-10-26 @ 11:36 AM
Study NCT ID:
NCT02340871
Status:
UNKNOWN
Last Update Posted:
2015-01-19
First Post:
2015-01-06
Brief Title:
Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases
Sponsor:
Rabin Medical Center
Organization:
Rabin Medical Center
Study Overview
Official Title:
Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases
Status:
UNKNOWN
Status Verified Date:
2014-12
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NGS
Brief Summary:
In Israel because of special qualification in neurogenetics during a 30 year career we have found characterized and treated at least 13 novel neurological diseases The genetic basis was elucidated with geneticist colleagues both in Israel and worldwide The diseases we have found encompass all the fields of pediatric neurology including intellectual disability epilepsy muscle-nerve disorders malformations of the brain microcephaly macrocephaly cerebellar ataxia chorea dystonia cerebral palsy and many other symptoms and signs
We are especially interested in consanguineous families in whom the parents are first or second degree cousins These families often bear autosomal - recessive diseases If the family is informative - with 2 or more affected children - then with current genetic techniques there is a good chance of finding the causative gene to this specific disease This is not only a theoretical - academic accomplishment In practice after discovering the gene the family is given genetic counseling and in their further pregnancies the geneticists will examine either by preimplantation genetic diagnosis PGD or amniocentesis if the embryo is affected or not In the early stages of the pregnancy if the embryo is indeed affected by the disease caused by the gene we have found and the religious official consents genetic counseling can offer termination of pregnancy to the couple
Needless to say we know the immense burden of an affected child on the family community and society The parents are guilt-ridden the affected child draws extensive resources from educational health and rehabilitation authorities We can contribute to the well-being of the family and the clan because many times the relatives are affected
We can perform sophisticated genetic studies such as Whole Genome Sequencing and Whole Exome SequencingAfter an informative family is recruited to the study we will explain the aims of the research The parents and eligible patients will sign informed consent forms according to the local Helsinki Board Blood samples will be taken in Israel DNA extracted in the Israeli lab and then shipped coded to the researchers in USA or Germany If the researchers will find a new gene the family will be notified and given appropriate genetic counseling We will continue to follow and treat the family onwards
We are especially interested in consanguineous families in whom the parents are first or second degree cousins These families often bear autosomal - recessive diseases If the family is informative - with 2 or more affected children - then with current genetic techniques there is a good chance of finding the causative gene to this specific disease This is not only a theoretical - academic accomplishment In practice after discovering the gene the family is given genetic counseling and in their further pregnancies the geneticists will examine either by preimplantation genetic diagnosis PGD or amniocentesis if the embryo is affected or not In the early stages of the pregnancy if the embryo is indeed affected by the disease caused by the gene we have found and the religious official consents genetic counseling can offer termination of pregnancy to the couple
Needless to say we know the immense burden of an affected child on the family community and society The parents are guilt-ridden the affected child draws extensive resources from educational health and rehabilitation authorities We can contribute to the well-being of the family and the clan because many times the relatives are affected
We can perform sophisticated genetic studies such as Whole Genome Sequencing and Whole Exome SequencingAfter an informative family is recruited to the study we will explain the aims of the research The parents and eligible patients will sign informed consent forms according to the local Helsinki Board Blood samples will be taken in Israel DNA extracted in the Israeli lab and then shipped coded to the researchers in USA or Germany If the researchers will find a new gene the family will be notified and given appropriate genetic counseling We will continue to follow and treat the family onwards
Detailed Description:
In Israel there are various sub-populations with a tendency to consanguinity Among them are the Arab-Muslim Druze Bedouin Sephardi Jews and to a lesser extent Ashkenazi Jews
Consanguinity especially between 2 first cousins exposes the couple to various genetic diseases at a risk of 25 per each pregnancy This phenomenon is based on Mendelian autosomal-recessive inheritance When the couple is from the same family or clan or even from the same ethnic origin there is a probability that dormant abnormal genes will pass through generations of intermarriage thus rendering the couple as carriers and producing a risk of 25 for the offspring to be affected
Many of the autosomal-recessive diseases have neurological features such as developmental delay intellectual disability epilepsy and motor andor sensory impairment These diseases carry a heavy burden on the family community and the educational health and welfare authorities The disabled children are often handicapped go to special education programs are not independent in daily living tasks are often sick and in need of hospitalization They will grow up needing special housing facilities Their life span is usually shorter than normal These children are dependent on their parents they subdue the parents to misery interparental conflicts and susceptibility to divorces Most of the neurological diseases are untreatable nowadays Most of the medical effort focuses on their prevention For example by finding the gene for a specific neurological condition we could search for that same gene in the couples next pregnancy If the fetus is found to be affected we could offer genetic counseling and a possibility of pregnancy termination and so the family avoids the birth of an affected sibling
When an individual with a neurogenetic disease is enrolled to the study a careful history is taken to characterize the neurological syndrome to see if other family members are affected by the same condition and a pedigree is drawn We compare the neurological signs and symptoms to information data webs like PUBMED or Online Mendelian Inheritance in Man and if we dont find a similar description we refer to the family as harboring a new disease with a novel gene
We work with neurogenetic colleagues abroad like Dr Andy Singleton in National Institute of Aging NIH USA of Dr Markus Schuelke from Charite Hospital Berlin Germany
We take on ourselves to search for the families explain to them what are the purposes of the research and their consequences If we suspect a new gene we will ask the parents or patients to sign informed consent forms according to our approved Helsinki board We will take a sample of 10 cc blood in order to extract DNA The DNA will be extracted in the genetic lab in Israel A coded DNA will be sent to the researcher abroad After 12 years the sample will be returned coded to the lab in Israel
The researchers abroad will use homozygosity mapping techniques as well as NEXT GENERATION SEQUENCING like WHOLE EXOME SEQUENCING and WHOLE GENOME SEQUENCING
If a new gene is found we will arrange for proper genetic counseling and explain the implications of the genetic data on the individual and his family We will provide the family with symptomatic or palliative further therapy as needed
Consanguinity especially between 2 first cousins exposes the couple to various genetic diseases at a risk of 25 per each pregnancy This phenomenon is based on Mendelian autosomal-recessive inheritance When the couple is from the same family or clan or even from the same ethnic origin there is a probability that dormant abnormal genes will pass through generations of intermarriage thus rendering the couple as carriers and producing a risk of 25 for the offspring to be affected
Many of the autosomal-recessive diseases have neurological features such as developmental delay intellectual disability epilepsy and motor andor sensory impairment These diseases carry a heavy burden on the family community and the educational health and welfare authorities The disabled children are often handicapped go to special education programs are not independent in daily living tasks are often sick and in need of hospitalization They will grow up needing special housing facilities Their life span is usually shorter than normal These children are dependent on their parents they subdue the parents to misery interparental conflicts and susceptibility to divorces Most of the neurological diseases are untreatable nowadays Most of the medical effort focuses on their prevention For example by finding the gene for a specific neurological condition we could search for that same gene in the couples next pregnancy If the fetus is found to be affected we could offer genetic counseling and a possibility of pregnancy termination and so the family avoids the birth of an affected sibling
When an individual with a neurogenetic disease is enrolled to the study a careful history is taken to characterize the neurological syndrome to see if other family members are affected by the same condition and a pedigree is drawn We compare the neurological signs and symptoms to information data webs like PUBMED or Online Mendelian Inheritance in Man and if we dont find a similar description we refer to the family as harboring a new disease with a novel gene
We work with neurogenetic colleagues abroad like Dr Andy Singleton in National Institute of Aging NIH USA of Dr Markus Schuelke from Charite Hospital Berlin Germany
We take on ourselves to search for the families explain to them what are the purposes of the research and their consequences If we suspect a new gene we will ask the parents or patients to sign informed consent forms according to our approved Helsinki board We will take a sample of 10 cc blood in order to extract DNA The DNA will be extracted in the genetic lab in Israel A coded DNA will be sent to the researcher abroad After 12 years the sample will be returned coded to the lab in Israel
The researchers abroad will use homozygosity mapping techniques as well as NEXT GENERATION SEQUENCING like WHOLE EXOME SEQUENCING and WHOLE GENOME SEQUENCING
If a new gene is found we will arrange for proper genetic counseling and explain the implications of the genetic data on the individual and his family We will provide the family with symptomatic or palliative further therapy as needed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1ZIAAG000958-12 | NIH | None | httpsreporternihgovquickSearch1ZIAAG000958-12 |