Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00184847
Status:
SUSPENDED
Last Update Posted:
2008-03-28
First Post:
2005-09-12
Brief Title:
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Sponsor:
Radboud University Medical Center
Organization:
Radboud University Medical Center
Study Overview
Official Title:
Adenosine Receptor Involvement in Acute Ischemic Preconditioning of the Vascular Endothelium
Status:
SUSPENDED
Status Verified Date:
2008-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size This mechanism can be mimicked by several pharmacological substances such as acetylcholine and adenosine
To detect ischemia-reperfusion injury in humans in vivo Kharbanda et al developed a method in which endothelial dysfunction represents the effects of ischemic preconditioning This method however uses acetylcholine to measure endothelial function before and after forearm ischemia We the investigators at Radboud University hypothesize that the use of acetylcholine in this model reduces ischemia-reperfusion injury Therefore we will compare this protocol with a protocol in which endothelial function is only measured after ischemia We expect an increase in ischemia-reperfusion injury when endothelial function is only measured after the forearm ischemia
After determining the optimal method to measure ischemia-reperfusion injury of the vascular endothelium we will determine the effect of acute and chronic caffeine an adenosine receptor antagonist on ischemic preconditioning With this study we expect to find that adenosine mimics ischemic preconditioning of the vascular endothelium Moreover we expect to find that acute caffeine intake reduces ischemia-reperfusion injury whereas chronic caffeine intake does not This study will increase our knowledge about the mechanism of ischemic preconditioning and may also provide leads to exploit this endogenous protective mechanism in a clinical setting
To detect ischemia-reperfusion injury in humans in vivo Kharbanda et al developed a method in which endothelial dysfunction represents the effects of ischemic preconditioning This method however uses acetylcholine to measure endothelial function before and after forearm ischemia We the investigators at Radboud University hypothesize that the use of acetylcholine in this model reduces ischemia-reperfusion injury Therefore we will compare this protocol with a protocol in which endothelial function is only measured after ischemia We expect an increase in ischemia-reperfusion injury when endothelial function is only measured after the forearm ischemia
After determining the optimal method to measure ischemia-reperfusion injury of the vascular endothelium we will determine the effect of acute and chronic caffeine an adenosine receptor antagonist on ischemic preconditioning With this study we expect to find that adenosine mimics ischemic preconditioning of the vascular endothelium Moreover we expect to find that acute caffeine intake reduces ischemia-reperfusion injury whereas chronic caffeine intake does not This study will increase our knowledge about the mechanism of ischemic preconditioning and may also provide leads to exploit this endogenous protective mechanism in a clinical setting
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None