Ignite Creation Date:
2024-05-05 @ 9:36 AM
Last Modification Date:
2024-10-26 @ 9:01 AM
Study NCT ID:
NCT00000406
Status:
COMPLETED
Last Update Posted:
2013-04-30
First Post:
1999-11-03
Brief Title:
Effects of Strength Training on Knee Osteoarthritis
Sponsor:
Indiana University
Organization:
Indiana University
Study Overview
Official Title:
Effects of Strength Training on Knee Osteoarthritis OA
Status:
COMPLETED
Status Verified Date:
2013-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To understand the effects of leg strengthening exercise we will study the effects of strength training of the legs in four groups of people 1 osteoarthritis OA with knee pain 2 OA without knee pain 3 no OA but elderly with knee pain and 4 normal elderly with no OA or knee pain In each of the first three groups we will look at whether people who do strength training have less pain andor slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening range-of-motion exercises We are including the fourth group to find out whether people with OA groups 1 2 have the same response to strength training as healthy elderly people and whether those with knee pain groups 1 3 have the same response to training as those without joint pain
Detailed Description:
Several studies have confirmed that weak leg muscles are associated with osteoarthritis OA of the knee Studies of body composition in these people have also shown that despite being weaker people with OA have significantly greater muscle mass than those without OA suggesting that those with OA may have the potential to greatly increase their strength However research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic x-ray analysis To understand the effects of leg strengthening exercise we will perform a randomized clinical trial of lower extremity strength training using four subgroups of people 1 OA with knee pain 2 OA without knee pain 3 no OA with knee pain and 4 normal elderly with no OA or knee pain
In each of the first three groups we will determine whether people assigned to strength training have lower pain scores andor slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises ie range-of-motion exercises We are including the fourth group to determine whether those with OA groups 1 2 exhibit the same response to strength training as healthy elderly people and whether those with knee pain groups 1 3 have the same response to training as those without joint pain We will also prospectively monitor changes in body composition and bone mass quality of life and symptoms of depression
In each of the first three groups we will determine whether people assigned to strength training have lower pain scores andor slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises ie range-of-motion exercises We are including the fourth group to determine whether those with OA groups 1 2 exhibit the same response to strength training as healthy elderly people and whether those with knee pain groups 1 3 have the same response to training as those without joint pain We will also prospectively monitor changes in body composition and bone mass quality of life and symptoms of depression
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIAMS-022 | US NIH GrantContract | None | httpsreporternihgovquickSearchP60AR020582 |
| P60AR020582 | NIH | None | None |