Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00188279
Status:
COMPLETED
Last Update Posted:
2018-10-11
First Post:
2005-09-09
Brief Title:
Minimum Dose Computed Tomography of the Thorax for Follow-up in Patients With Resected Lung Carcinoma
Sponsor:
University Health Network Toronto
Organization:
University Health Network Toronto
Study Overview
Official Title:
Minimum Dose Computed Tomography of the Thorax for Follow-up in Patients With Resected Lung Carcinoma
Status:
COMPLETED
Status Verified Date:
2018-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to help decide whether a CAT scan performed at a very low dose of radiation Minimum dose CT scan is better than a Chest X-Ray in detecting recurrence of lung cancer in the chest after surgery
Detailed Description:
Lung Carcinoma is expected to kill 18900 men and women in Canada in 2004 This is more than the combined total for the next three common cancers The most important factor that determines patient survival is the stage of disease at presentation Surgical resection is the best chance of cure However patients who undergo lung resection with curative intent have a significant incidence of a second lung cancer at 2 per year and a recurrence rate of 38 at 5 years The current follow-up of these patients relies on periodic physical examination and chest radiographyCXR However CXR is insensitive in the detection of lung nodules when compared to standard Computed Tomography of the thorax SDCT Computed Tomography detects smaller lung nodules than CXR however the radiation dose from a SDCT is roughly equivalent to 20 CXR examinations Screening studies using Low Dose CT of the Thorax LDCT in subjects at high risk for lung cancer have demonstrated that LDCT detects three times as many nodules as CXR and four times as many primary lung cancers at one-third the dose of SDCT Phantom and clinical work with LDCT performed at UHNMSH suggests that a further reduction in radiation dose Minimum Dose CT -MnDCT is possible for nodule detection Minimum dose CT is performed at a dose one sixth of a SDCTIn addition if MnDCT is confirmed to be a more sensitive nodule detection technique it could be used to
1 Increase the interval between repeat out-patient assessment and thereby 2 Reduce the overall cost of surveillance and inconvenience to the patient and 3 Free up clinic time for the surgeon to review more patients and reduce waiting lists
1 Increase the interval between repeat out-patient assessment and thereby 2 Reduce the overall cost of surveillance and inconvenience to the patient and 3 Free up clinic time for the surgeon to review more patients and reduce waiting lists
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None