Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173290
Status:
UNKNOWN
Last Update Posted:
2008-06-03
First Post:
2005-09-12
Brief Title:
Cytokine Regulation of Natural Killer Receptors in Inhibiting Activated T Cell Function
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study proposal the investigators will extend their previous studies and examine the kinetic cytotoxic activity with concordant expression of inhibitory natural killer NK receptors iNKR on activated T cells The inhibitory role of cytokines will be defined by utilizing the investigators previously established models of mixed lymphocytes and tumor cells coculture to analyze the expression and activity of cytokines involved in the regulation of iNKRs on cancer-encountered T cells
Detailed Description:
In our extended studies we have directly examined the expressions of various inhibitory natural killer cell Receptors iNKRs on Tumor-infiltrating lymphocytes TILs derived from human Cervical cancer CC by triple-color flow cytometry with combination of different surface markers We found up-regulated expression of certain iNKRs CD94NKG2A in TILs and in mixed lymphocyte-cancer cell cocultures In our previous studies we demonstrated that certain cytokines including IL-10 TGF-beta Sheu et al Journal of Immunology 2001 1672972-2978 and IL-15 Sheu et al Cancer Research 2005 652921-2929 can be expressed by CC cells We further demonstrated that activated T cells bear iNKRs which inhibit cytotoxic activity iNKRs are proposed to restrain the T cell receptor TCR-mediated cytolysis We found that CC cells had altered HLA-A -B and -C molecules in a cancer microenvironment The acquisition of both NK-like activity and expression of iNKRs by these T cells is parallel to prevent damage to normal host cells However there is also limited knowledge about the regulatory role of iNKR expression in T cell cytotoxicity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NSC93-2314-B002-164 | None | None | None |
| NTUH 94-S045 | None | None | None |
| NTUH 95-0399 | None | None | None |
| NTUCM-9406 | None | None | None |
| NSC93-2314-B002-065 | None | None | None |