Ignite Creation Date:
2024-05-06 @ 3:29 AM
Last Modification Date:
2024-10-26 @ 11:34 AM
Study NCT ID:
NCT02305407
Status:
UNKNOWN
Last Update Posted:
2017-08-22
First Post:
2014-11-19
Brief Title:
Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
Sponsor:
Huashan Hospital
Organization:
Huashan Hospital
Study Overview
Official Title:
Neurocognitive and Radiological Assessments in Adult Patients With Moyamoya Disease Undergoing Surgical Revascularization
Status:
UNKNOWN
Status Verified Date:
2017-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NRAAMUS
Brief Summary:
Adult patients with moyamoya disease MMD are reported to suffer from considerable impairment of executive functionattention Although reduced cerebrovascular reserve CVR in frontal areas has been detected by perfusion MRI and then confirmed to be associated with executive dysfunction in adult MMD the structural and functional changes is still unclear with progression of executive dysfunction Furthermore it is very important to study the association between the neurocognitive and radiological improvement after surgical revascularization so as to help detecting cerebral regions which are involved in executive deterioration or improvement after surgery Then the investigators can determine whether these regions can be used as indicators to decide rational therapeutic schedule and timing of adult MMD with executive dysfunction
Thus the aim of this study is to primarily find out the neuropsychological and radiological correlates in adult MMD and then to quantitatively evaluate the effectiveness of surgical revascularization in prevention of executive dysfunction in adult MMD
Thus the aim of this study is to primarily find out the neuropsychological and radiological correlates in adult MMD and then to quantitatively evaluate the effectiveness of surgical revascularization in prevention of executive dysfunction in adult MMD
Detailed Description:
Previous studies of adult moyamoya disease MMD have revealed that vascular cognitive impairment VCI is the consequence of ischemic damage to dynamic factors such as cerebral hypoperfusion rather than to cerebral gray matter However it is still unclear which regions are affected by MMD and how these regions respond to the progressive cognitive decline In other way the investigators need to detect spatial patterns in the brain activity of MMD in order to understand its pathophysiological nature
Surgical revascularization has been accepted as the only effective form of treatment in preventing future ischemic episodes However its effectiveness in cognitive protection is still unknown Thus the investigators determine to quantitatively evaluate cognitive and radiological outcomes in adult MMD postoperatively and during follow-ups
Surgical revascularization has been accepted as the only effective form of treatment in preventing future ischemic episodes However its effectiveness in cognitive protection is still unknown Thus the investigators determine to quantitatively evaluate cognitive and radiological outcomes in adult MMD postoperatively and during follow-ups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None