Ignite Creation Date:
2024-05-06 @ 3:28 AM
Last Modification Date:
2024-10-26 @ 11:34 AM
Study NCT ID:
NCT02299245
Status:
UNKNOWN
Last Update Posted:
2015-07-14
First Post:
2014-11-14
Brief Title:
Rosuvastatin Effect on Telomere-telomerase System in ACS
Sponsor:
Xiao-dong Zhuang
Organization:
Sun Yat-sen University
Study Overview
Official Title:
Different Doses Rosuvastatin Effect on Telomere-telomerase System in Acute Coronary Syndrome Patients After Percutaneous Coronary INtervention RETAIN Study
Status:
UNKNOWN
Status Verified Date:
2015-07
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coronary heart disease CHD is one of the diseases characterised by biological aging as one of the important risk factors in several epidemiological studies The mean telomere length and telomerase activity serve as markers for the biological age at the cellular level with shorter telomeres and lower telomerase activity defining the increased biological age Telomere length and telomerase activity therefore correlates with the risk of CHD and atherosclerosis A present study states that the treatment with a statin is associated with a reduction in the number of clinical events but only in individuals with increased risk based on their telomere length This suggests a positive relationship of telomere and telomerase system with the treatment with statins in CHD patients
Detailed Description:
Coronary heart disease CHD is identified as one of the diseases characterised by biological aging as one of the important risk factors in several epidemiological studies Premature biological aging is distinct from chronological aging and may predispose the individual to myocardial infarction atherosclerosis and CHD in particular The mean telomere length and telomerase activity serve as markers for the biological age at the cellular level with shorter telomeres and lower telomerase activity defining the increased biological age Telomere length and telomerase activity therefore correlates with the risk of CHD and atherosclerosis Statins serve as the drugs of obvious choice based on their well established efficacy and safety profiles for the treatment of CHD and associated atherosclerosis A present clinical study states that the treatment with a statin is associated with a reduction in the number of clinical events but only in individuals with increased risk based on their telomere length This suggests a positive relationship of telomere and telomerase system with the risk of CHD and therefore would help clinicians to categorise the patient populations based on their leucocyte telomere length for treatment with statins
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None