Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00179829
Status:
COMPLETED
Last Update Posted:
2008-01-15
First Post:
2005-09-10
Brief Title:
WT1 for the Detection of Minimal Residual Disease
Sponsor:
Ann Robert H Lurie Childrens Hospital of Chicago
Organization:
Ann Robert H Lurie Childrens Hospital of Chicago
Study Overview
Official Title:
Detection of Minimal Residual Disease in Newly Diagnosed Patients With Leukemia and Those Who Undergo a Bone Marrow Transplant Using the Wilms Tumor Suppressor Gene WT1 as a Marker By RT-PCR
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if WT1 is an adequate measurement of minimal residual disease in leukemic patients
Detailed Description:
Patients with acute Leukemia may have a large number of leukemic cells at the time that leukemia is evident clinically At the time that we determine that a patient is in complete remission CR the patient may still have leukemic cells present in smaller quantities One of the most important factors in the successful treatment of patients with leukemia is the ability to determine if the eradication of leukemia has been achieved The determination of Minimal Residual Disease may be important in the determination of the therapy that a given patient will receive as determined by the level of residual disease
WT1 gene function and expression The WT1 gene is a candidate gene for Wilms tumor which is thought to arise as a result from inactivation of both alleles of the WT1 gene located at chromosome 11p13 The WT1 gene has been considered a tumor suppressor gene because intragenic deletions or mutations are found in tumors germline mutations have been found in-patients with leukemia and mediates growth suppression of Wilms tumor cells expressing a WT1 splicing variant
WT1 gene function and expression The WT1 gene is a candidate gene for Wilms tumor which is thought to arise as a result from inactivation of both alleles of the WT1 gene located at chromosome 11p13 The WT1 gene has been considered a tumor suppressor gene because intragenic deletions or mutations are found in tumors germline mutations have been found in-patients with leukemia and mediates growth suppression of Wilms tumor cells expressing a WT1 splicing variant
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None