Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00172224
Status:
COMPLETED
Last Update Posted:
2012-11-14
First Post:
2005-09-12
Brief Title:
Dynamic Magnetic Resonance MR Study in Evaluating the Vertebral Bone Marrow Perfusion and Its Related Research
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Dynamic MR Study in Evaluating the Vertebral Bone Marrow Perfusion and Its Related Research
Status:
COMPLETED
Status Verified Date:
2012-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The etiology and pathogenesis of osteoporosis has been extensively discussed The relationship between bone blood circulation and the formation of bony trabeculae has been less understood There is plenty of indirect evidence highly suggestive of the correlation between these two factors such as the number of blood vessels in the per unit area of the bone marrow was decreased in the osteoporotic bone indicating the possible role of a microvascular defect in the pathogenesis of osteoporosis
Furthermore the bone mineral density in severe arteriosclerotic patients was lower than in the less affected subjects In a large scale epidemiologic study diminished bone mineral density was strongly associated with increased deaths from stroke Osteopenia was also associated with an increased risk of stroke These reports highly suggest the effect of ischemia on bone metabolism and make the investigators more interested in further investigation
A dynamic contrast-enhanced magnetic resonance MR study was used recently in evaluating the blood perfusion of bone tumors This method also has a strong correlation with the microsphere blood flow measurements The investigator TF Shih used the dynamic MR in her recent two researches
1 To differentiate benign versus malignant spinal compression fractures
2 To evaluate the blood perfusion of non-fractured normal-appearing vertebral bodies and find its significant correlation with aging and sex
The alterations of bone marrow perfusion are synchronous with the changes of bone mineral density Thus based on the investigators previous research work they propose to further explore the relationship between bone marrow perfusion and bone mineral density in different age groups
Furthermore the bone mineral density in severe arteriosclerotic patients was lower than in the less affected subjects In a large scale epidemiologic study diminished bone mineral density was strongly associated with increased deaths from stroke Osteopenia was also associated with an increased risk of stroke These reports highly suggest the effect of ischemia on bone metabolism and make the investigators more interested in further investigation
A dynamic contrast-enhanced magnetic resonance MR study was used recently in evaluating the blood perfusion of bone tumors This method also has a strong correlation with the microsphere blood flow measurements The investigator TF Shih used the dynamic MR in her recent two researches
1 To differentiate benign versus malignant spinal compression fractures
2 To evaluate the blood perfusion of non-fractured normal-appearing vertebral bodies and find its significant correlation with aging and sex
The alterations of bone marrow perfusion are synchronous with the changes of bone mineral density Thus based on the investigators previous research work they propose to further explore the relationship between bone marrow perfusion and bone mineral density in different age groups
Detailed Description:
The etiology and pathogenesis of osteoporosis has been extensively discussed The relationship between bone blood circulation and the formation of bony trabeculae has been less understood There is plenty of indirect evidence highly suggestive of the correlation between these two factors such as the number of blood vessels in the per unit area of the bone marrow was decreased in the osteoporotic bone indicating the possible role of a microvascular defect in the pathogenesis of osteoporosis
Furthermore the bone mineral density in severe arteriosclerotic patients was lower than in the less affected subjects In a large scale epidemiologic study diminished bone mineral density was strongly associated with increased deaths from stroke Osteopenia was also associated with an increased risk of stroke These reports highly suggest the effect of ischemia on bone metabolism and make the investigators more interested in further investigation
A dynamic contrast-enhanced magnetic resonance MR study was used recently in evaluating the blood perfusion of bone tumors This method also has a strong correlation with the microsphere blood flow measurements The investigator TF Shih used the dynamic MR in her recent two researches
1 To differentiate benign versus malignant spinal compression fractures
2 To evaluate the blood perfusion of non-fractured normal-appearing vertebral bodies and find its significant correlation with aging and sex
The alterations of bone marrow perfusion are synchronous with the changes of bone mineral density Thus based on the investigators previous research work they propose to further explore the relationship between bone marrow perfusion and bone mineral density in different age groups
Furthermore the bone mineral density in severe arteriosclerotic patients was lower than in the less affected subjects In a large scale epidemiologic study diminished bone mineral density was strongly associated with increased deaths from stroke Osteopenia was also associated with an increased risk of stroke These reports highly suggest the effect of ischemia on bone metabolism and make the investigators more interested in further investigation
A dynamic contrast-enhanced magnetic resonance MR study was used recently in evaluating the blood perfusion of bone tumors This method also has a strong correlation with the microsphere blood flow measurements The investigator TF Shih used the dynamic MR in her recent two researches
1 To differentiate benign versus malignant spinal compression fractures
2 To evaluate the blood perfusion of non-fractured normal-appearing vertebral bodies and find its significant correlation with aging and sex
The alterations of bone marrow perfusion are synchronous with the changes of bone mineral density Thus based on the investigators previous research work they propose to further explore the relationship between bone marrow perfusion and bone mineral density in different age groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NSC 92-2314-B-002-172 | None | None | None |
| NSC 91-2314-B-002-395 | None | None | None |