Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00178516
Status:
COMPLETED
Last Update Posted:
2009-07-30
First Post:
2005-09-13
Brief Title:
Vitamin E and Male Infertility
Sponsor:
University of Rochester
Organization:
University of Rochester
Study Overview
Official Title:
Vitamin E and Male Infertility
Status:
COMPLETED
Status Verified Date:
2009-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to determine whether there is a correlation between the levels of Vitamin E in sperm and sperm DNA fragmentation
Previous research has shown that damage to the DNA in sperm may cause infertility or increase the chances of miscarriage if the damage is extensive eg present in the overwhelming majority of sperm Some studies suggest that DNA damage can be caused by oxidative stress Antioxidants such as Vitamin E which are present in some foods can prevent damage to cells from free radicals which are naturally present by-products of metabolism We ask whether there is a correlation between sperm DNA damage and Vitamin E
Previous research has shown that damage to the DNA in sperm may cause infertility or increase the chances of miscarriage if the damage is extensive eg present in the overwhelming majority of sperm Some studies suggest that DNA damage can be caused by oxidative stress Antioxidants such as Vitamin E which are present in some foods can prevent damage to cells from free radicals which are naturally present by-products of metabolism We ask whether there is a correlation between sperm DNA damage and Vitamin E
Detailed Description:
Sperm DNA damage is an emerging cause of male infertility that is likely to be more common among men with increased reactive oxygen species in the ejaculate Vitamin E can protect the sperm membrane from oxidative damage and increased levels are associated with low levels of reactive oxygen species This is a study of Vitamin E levels in the spermatozoa and sera of 48 infertile men and 20 fertile men as a control group to look for correlations between sperm vitamin E levels and the degree of sperm DNA fragmentation Dietary intake of antioxidants will also be included
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None