Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00170521
Status:
TERMINATED
Last Update Posted:
2010-08-27
First Post:
2005-09-12
Brief Title:
Mol Epi GrAS in Nicaragua
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Leon Nicaragua
Status:
TERMINATED
Status Verified Date:
2006-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the epidemiology of throat isolates of group A streptococci among 3-15 year-old children with pharyngitis sore throat living in Leon Nicaragua
Detailed Description:
Streptococcus pyogenes GrAS is a human pathogen that leads to great disease burden throughout the world In the United States an estimated 30 million infections occur yearly Most of these are local infections of the skin or the throat but still lead to considerable use of health-care resources These common simple forms of GrAS disease may progress to or be followed by the more serious GrAS-related illnesses acute rheumatic fever post-streptococcal glomerulonephritis streptococcal toxic shock syndrome sepsis pneumonia or other invasive illnesses Outside the US in the developing world the burden of GrAS-related disease is presumed to be even higher but is not completely elucidated in many of the poorer regions of the world It is known though that rheumatic heart disease causes more cardiovascular morbidity in the children of the world than any other illness Although the incidence of rheumatic fever in the US has fallen to levels of approximately 05 per 100000 per year in some areas the developing worlds children still have rates over 100 per 100000 per year The percentage of cardiac admissions attributable to rheumatic heart disease in hospitals located in the developing world remains in the range of 30 to 50 where it has been studied GrAS is one of the best characterized human pathogens with regards to its microbiology its spectrum of diseases and its ability to lead to serious sequelae such as rheumatic fever and glomerulonephritis Yet efforts to control it through the use of antibiotics have been only partially successful in the United States and largely unsuccessful in the developing world The health impact of uncomplicated streptococcal infections such as pharyngitis and the less common but more severe diseases such as rheumatic heart disease must be better studied in order to move forward with control measures In this study patients aged 3-15 presenting with sore throat fever and cervical lymphadenopathy will be examined and a throat swab will be submitted to the lab for culture All of these patients will be treated with either benzathine penicillin or if they have a history of allergy to penicillin oral erythromycin The parent will be given a follow-up appointment to convey the result of the culture and to evaluate the course of the childs illness Children presenting with sore throat only will be cultured and given a follow-up appointment to return after the result of the culture is known Antibiotic treatment is given only if the culture is positive for group A streptococci Within this algorithm is latitude for the physician to treat any patient based on clinical signs and symptoms and the concern that a particular child may not return for treatment if it is delayed based on the culture result The overriding goal is the prevention of acute rheumatic fever and suppurative complications The primary objective of this study is to characterize the GrAS isolates genotypically emm type or sub-type The secondary objective is to describe the epidemiology of throat isolates of GrAS among 3- to 15- year old children with pharyngitis living in Leon Nicaragua Primary endpoint of the study is the frequency and proportion of each emm-type among children with pharyngitis Secondary Endpoints for the study are as follows The proportion of children with pharyngitis from whom GrAS is isolated The minimal incidence of GrAS pharyngitis in children based on annual cases per 100000 children in the catchment areas The age gender and ethnicity-specific minimal incidence rates of GrAS pharyngitis in children living in the catchment areas
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Leon GrAS2000 | None | None | None |