Ignite Creation Date:
2024-05-06 @ 3:26 AM
Last Modification Date:
2024-10-26 @ 11:34 AM
Study NCT ID:
NCT02292810
Status:
UNKNOWN
Last Update Posted:
2014-11-17
First Post:
2014-11-13
Brief Title:
Acute Effects of Inspiratory Muscle Exercise on Glucose Level and Glucose Variability in Patients With Type 2 Diabetes
Sponsor:
Hospital de Clinicas de Porto Alegre
Organization:
Hospital de Clinicas de Porto Alegre
Study Overview
Official Title:
Acute Effects of Inspiratory Muscle Exercise on Glucose Level and Glucose Variability in Patients With Type 2 Diabetes
Status:
UNKNOWN
Status Verified Date:
2014-11
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Type 2 diabetes is associated with respiratory muscle weakness and autonomic neuropathy The exercise of inspiratory muscles has been investigating in various clinical situations and may cause similar benefits as the conventional exercises The assessment of glucose variability has been used as an alternative tool to evaluate the others mechanisms than the absolute values of glucose levels special during the exercise However the effect of inspiratory muscle exercise on glucose levels and glucose variability is not clear yet The aim of the proposed research is to evaluate the acute effects of inspiratory muscle exercise using a high load of 60 of MIP on glucose levels and glucose variability in patients with type 2 diabetes
Detailed Description:
High-intensity exercise of inspiratory muscle was able to reduce glucose levels in previous studies but the mechanisms underlying this reduction remain largely unknown The present study will investigate this phenomenon and whether confirmed the inspiratory muscle loading would be a new approach for lowering glucose levels and glucose variability in type 2 diabetes
The subjects with type 2 diabetes will be recruited from the ambulatory of the Hospital de Clinicas de Porto Alegre The patients will be randomized to inspiratory muscle exercise with a high intensity load MIP 60 or to exercise with a load placebo MIP 2 on two different days The subjects will come in the laboratory for three days consecutively during 2 weeks On the first day will be placed the CGMS device On the second day will be the controlled ventilation protocol with subsequently inspiratory muscle exercise using 2 or 60 of MIP as randomized a priori On the third day the CGMS will be removed Individuals who are using beta-blockers will be advised to withdraw the medication 24 hours before the protocols During all protocols will be recorded the continuous blood pressure to assess heart rate and blood pressure variabilities both time and frequency domains will be analyzed Also the calf blood flow inspiratory pressure end-tidal carbon dioxide and oxygen saturation will be taking
The subjects with type 2 diabetes will be recruited from the ambulatory of the Hospital de Clinicas de Porto Alegre The patients will be randomized to inspiratory muscle exercise with a high intensity load MIP 60 or to exercise with a load placebo MIP 2 on two different days The subjects will come in the laboratory for three days consecutively during 2 weeks On the first day will be placed the CGMS device On the second day will be the controlled ventilation protocol with subsequently inspiratory muscle exercise using 2 or 60 of MIP as randomized a priori On the third day the CGMS will be removed Individuals who are using beta-blockers will be advised to withdraw the medication 24 hours before the protocols During all protocols will be recorded the continuous blood pressure to assess heart rate and blood pressure variabilities both time and frequency domains will be analyzed Also the calf blood flow inspiratory pressure end-tidal carbon dioxide and oxygen saturation will be taking
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None