Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00174070
Status:
UNKNOWN
Last Update Posted:
2005-11-03
First Post:
2005-09-13
Brief Title:
Etiologies and Outcomes of Acute Respiratory Failure in Community
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Etiologies and Outcomes Analysis of Acute Respiratory Failure in Community
Status:
UNKNOWN
Status Verified Date:
2005-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute respiratory failure ARF remains a common reason for admission to the intensive care unit ICU ARF to be present in 32 of patients on ICU admission with a further 24 of patients developing ARF during the ICU stay A total of 56 of all ICU admissions for a length of 48 h had ARF at some point during their stay The incidence of ARF was from 886 to 1371 hospitalizations per 100000 residents The incidence of ARF was found to increase nearly exponentially with each decade until age 85 years However there is still paucity data about etiology and outcomes of acute respiratory failure happened in community
Mortality of ARF in critically ill patients is between 40 and 65 Independent hazards for ARF mortality include older age severe chronic co-morbidities HIV active malignancy cirrhosis certain precipitating events trauma drug overdose bone marrow transplant and multiple organ system failure MOSF 7-9 Mortality has also been associated with acute lung injury or bilateral infiltrates on chest radiograph and with an elevated acute physiology score
ARF patients form a large percentage of all ICU admissions and many factors might influence the final outcomes With the high incidence of ARF in ICU any improvement in the outcome of such population is likely to have marked effect on intensive care resource allocation We wish this study may provide some valuable information about acute respiratory failure in community and improve the outcome of these patients
Mortality of ARF in critically ill patients is between 40 and 65 Independent hazards for ARF mortality include older age severe chronic co-morbidities HIV active malignancy cirrhosis certain precipitating events trauma drug overdose bone marrow transplant and multiple organ system failure MOSF 7-9 Mortality has also been associated with acute lung injury or bilateral infiltrates on chest radiograph and with an elevated acute physiology score
ARF patients form a large percentage of all ICU admissions and many factors might influence the final outcomes With the high incidence of ARF in ICU any improvement in the outcome of such population is likely to have marked effect on intensive care resource allocation We wish this study may provide some valuable information about acute respiratory failure in community and improve the outcome of these patients
Detailed Description:
Acute respiratory failure ARF remains a common reason for admission to the intensive care unit ICU ARF to be present in 32 of patients on ICU admission with a further 24 of patients developing ARF during the ICU stay 1 A total of 56 of all ICU admissions for a length of 48 h had ARF at some point during their stay 1 The incidence of ARF was from 886 to 1371 hospitalizations per 100000 residents 2 3 The incidence of ARF was found to increase nearly exponentially with each decade until age 85 years However there is still paucity data about etiology and outcomes of acute respiratory failure happened in community
Mortality of ARF in critically ill patients is between 40 and 65 2 4-6 Independent hazards for ARF mortality include older age severe chronic co-morbidities HIV active malignancy cirrhosis certain precipitating events trauma drug overdose bone marrow transplant and multiple organ system failure MOSF 7-9 Mortality has also been associated with acute lung injury or bilateral infiltrates on chest radiograph 6 and with an elevated acute physiology score 9-10
ARF patients form a large percentage of all ICU admissions and many factors might influence the final outcomes With the high incidence of ARF in ICU any improvement in the outcome of such population is likely to have marked effect on intensive care resource allocation We wish this study may provide some valuable information about acute respiratory failure in community and improve the outcome of these patients
References
1 Vincent JL Akca S De Mendonca A et al The epidemiology of acute respiratory failure in critically ill patients Chest 2002 1211602-1609
2 Lewandowski K Mets J Deutschmann H et al Incidence severity and mortality of acute respiratory failure in Berlin Germany Am J Respir Crit Care Med 1995 1511121-1125
3 Behrendt CE Acute respiratory failure in the United States incidence and 31-day survival Chest 2000 1181100-1105
4 Miberg JA Davis DR Steinberg KP et al Improved survival of patients with acute respiratory distress syndrome ARDS 1983-1993 JAMA 1995 273306-309
5 Doyle LA Szaflarski N Modin GW et al Identification of patients with acute lung injury predictors of mortality Am J Respir Crit Care Med 1995 1521818-1824
6 Luhr OR Antonsen K Karlsson M et al Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden Denmark and Iceland The ARF Study Group Am J Respir Crit Care Med 1999 1591849-1861
7 Vasilyev S Schaap RN Mortensen JD Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units Chest 1995 1071083-1088
8 Stauffer JL Fayter NA Graves B et al Survival following mechanical ventilation for acute respiratory failure in adult men Chest 1993 1041222-1229
9 Knaus WA Prognosis with mechanical ventilation the influence of disease severity of disease age and chronic health status on survival from an acute illness Am Rev Respir Dis 1989 140S8-S13
10 Epstein SK Vuong V Lack of influence of gender on outcomes of mechanically ventilated medical ICU patients Chest 1999 116732-739
Mortality of ARF in critically ill patients is between 40 and 65 2 4-6 Independent hazards for ARF mortality include older age severe chronic co-morbidities HIV active malignancy cirrhosis certain precipitating events trauma drug overdose bone marrow transplant and multiple organ system failure MOSF 7-9 Mortality has also been associated with acute lung injury or bilateral infiltrates on chest radiograph 6 and with an elevated acute physiology score 9-10
ARF patients form a large percentage of all ICU admissions and many factors might influence the final outcomes With the high incidence of ARF in ICU any improvement in the outcome of such population is likely to have marked effect on intensive care resource allocation We wish this study may provide some valuable information about acute respiratory failure in community and improve the outcome of these patients
References
1 Vincent JL Akca S De Mendonca A et al The epidemiology of acute respiratory failure in critically ill patients Chest 2002 1211602-1609
2 Lewandowski K Mets J Deutschmann H et al Incidence severity and mortality of acute respiratory failure in Berlin Germany Am J Respir Crit Care Med 1995 1511121-1125
3 Behrendt CE Acute respiratory failure in the United States incidence and 31-day survival Chest 2000 1181100-1105
4 Miberg JA Davis DR Steinberg KP et al Improved survival of patients with acute respiratory distress syndrome ARDS 1983-1993 JAMA 1995 273306-309
5 Doyle LA Szaflarski N Modin GW et al Identification of patients with acute lung injury predictors of mortality Am J Respir Crit Care Med 1995 1521818-1824
6 Luhr OR Antonsen K Karlsson M et al Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden Denmark and Iceland The ARF Study Group Am J Respir Crit Care Med 1999 1591849-1861
7 Vasilyev S Schaap RN Mortensen JD Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units Chest 1995 1071083-1088
8 Stauffer JL Fayter NA Graves B et al Survival following mechanical ventilation for acute respiratory failure in adult men Chest 1993 1041222-1229
9 Knaus WA Prognosis with mechanical ventilation the influence of disease severity of disease age and chronic health status on survival from an acute illness Am Rev Respir Dis 1989 140S8-S13
10 Epstein SK Vuong V Lack of influence of gender on outcomes of mechanically ventilated medical ICU patients Chest 1999 116732-739
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None