Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173537
Status:
UNKNOWN
Last Update Posted:
2012-12-27
First Post:
2005-09-12
Brief Title:
Genetic Research of Bone Morphogenetic Protein Receptor-II Gene in Taiwanese Patient With Primary Pulmonary Hypertension
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Genetic Research of Bone Morphogenetic Protein Receptor-II Gene in Taiwanese Patient With Primary Pulmonary Hypertension
Status:
UNKNOWN
Status Verified Date:
2012-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Primary pulmonary hypertension PPH is a rare lung disorder in which the blood pressure in the pulmonary artery rises far above normal levels for no apparent reason The pulmonary artery is a blood vessel carrying oxygen-poor blood from the right ventricle one of the hearts pumping chambers to the lungs In the lungs the blood picks up oxygen then flows to the hearts left side where the left ventricle pumps it to the rest of the body through the aorta In the United States an estimated 500 to 1000 new cases of primary pulmonary hypertension are diagnosed each year The greatest number is reported in women between ages 20 and 40 However men and women in all age ranges as well as very young children can develop PPH Researchers have identified more than 40 BMPR2 mutations that can cause primary pulmonary hypertension Many of these mutations introduce a stop signal that halts protein production prematurely decreasing the amount of functional BMPR2 protein Other mutations prevent the BMPR2 protein from reaching the cell surface or alter its structure so it cannot form a complex with other proteins It remains unclear how BMPR2 mutations cause primary pulmonary hypertension Researchers suggest that a mutation in this gene prevents cell death or promotes cell proliferation resulting in an overgrowth of cells in the blood vessels of the lungs Cell overgrowth can narrow the diameter of the vessels restricting blood flow and resulting in elevated blood pressure However it has not yet been reported regarding the genetic variants in Taiwan Further details have been described in this project proposal
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None