Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00179946
Status:
COMPLETED
Last Update Posted:
2018-07-30
First Post:
2005-09-12
Brief Title:
HLA Matching - Unrelated Umbilical Cord Blood Transplantation
Sponsor:
Ann Robert H Lurie Childrens Hospital of Chicago
Organization:
Ann Robert H Lurie Childrens Hospital of Chicago
Study Overview
Official Title:
Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation
Status:
COMPLETED
Status Verified Date:
2018-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood UCB transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation
Detailed Description:
The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood UCB transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation
The study will answer the following questions
1 Is HLA matching beneficial to unrelated UCB transplantation
2 Which HLA loci HLA-A B C DRB1 or BQB1 isare important to math or alternatively to mismatch to improve graft survival
3 Which HLA loci HLA-A B C DRB1 or BQB1 mismatches isare permissive mismatches or well tolerated mismatches
4 What level of typing resolution low intermediate or hgh is required to perform patientdonor HA matching
By studying the cells and blood of donors and recipients we may learn more about improving the tissue matching between unrelated donors and their recipients Also we hope to learn if an additional level of matching testing improves the results of the transplant treatment Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients
The study will answer the following questions
1 Is HLA matching beneficial to unrelated UCB transplantation
2 Which HLA loci HLA-A B C DRB1 or BQB1 isare important to math or alternatively to mismatch to improve graft survival
3 Which HLA loci HLA-A B C DRB1 or BQB1 mismatches isare permissive mismatches or well tolerated mismatches
4 What level of typing resolution low intermediate or hgh is required to perform patientdonor HA matching
By studying the cells and blood of donors and recipients we may learn more about improving the tissue matching between unrelated donors and their recipients Also we hope to learn if an additional level of matching testing improves the results of the transplant treatment Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None