Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00172445
Status:
WITHDRAWN
Last Update Posted:
2012-12-10
First Post:
2005-09-12
Brief Title:
Clinical Studies of Kikuchis Disease
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
WITHDRAWN
Status Verified Date:
2004-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Kikuchi-Fujimoto disease is a distinctive syndrome of necrotizing lymphadenitis which was formally described in 1972 by two Japanese pathologists Kikuchi and Fujimoto It is a benign self-limited disease that predominantly occurs in young women It was more common in Asian people especially in Japanese The most frequent clinical presentations are fever 3050 and cervical lymphadenopathy often tender in palpable Other lymph node regions can be affected and hepatosplenomegaly may be present The laboratory findings include leucopenia with atypical lymphocytosis ESR transaminases and lactate dehydrogenase are often raised The clinical features are easily confused with other conditions particularly lymphoma Therefore the diagnosis depends on the pathological findings The typical findings are paracortical lesions consisting of patchy zones of eosinophilic fibrinoid necrosis and abundant karyorrhexis In general spontaneous resolution of symptoms and signs within a few months can be expected without treatmentFor decades the etiology of Kikuchis disease has been speculated Although the perforin and Fas pathways of cytotoxic T cells induce an abundance of apoptosis and thus induce necrotizing lesions the trigger factor is unknown Since the disease can precede or occur in association with a connective tissue disorder especially SLE the autoimmune contribution to the etiology has also been speculated However the clinical course of Kikuchis disease often sudden onset and spontaneous resolution the frequent flu-like or upper respiratory prodrome and the prominence of cervical lymphadenopathy support a viral cause Evidence for a viral cause also includes peripheral blood atypical lymphocytosis and elevated serum IFN-a or 2-5 oligoadenylate synthetase levels Several infectious agents have been suggested including bacteria eg Brucella Yersinia parasites eg toxoplasmosis and viruses eg EBV CMV HHV6 HHV8 parvovirus B19 HTLV HIVThe aim of this study is to collect cases of Kikuchi disease in bureau of NHI and NTUH We will analyze the incidence rate age of onset sex season of onset and clinical course to see if there is any clustered cases or nosocomial infection Then we will study the etiology of Kikuchis disease especially the infection causes by analyzing pathologic specimen and serology We hope to find out the etiology of Kikuchis disease and the new treatment
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None