Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00176345
Status:
UNKNOWN
Last Update Posted:
2005-09-15
First Post:
2005-09-11
Brief Title:
Impact of Exercise Training on Endothelial Function in CAD
Sponsor:
University of Leipzig
Organization:
University of Leipzig
Study Overview
Official Title:
Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease
Status:
UNKNOWN
Status Verified Date:
2005-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Bradykinin has been identified to contribute to the release of nitric oxide NO prostacyclin and EDHF through activation of specific bradykinin 2 B2 receptors which is finally promoting a vasodilatory respone Regular physical exercise training results in an improvement of endothelial function in patients with CAD These positive effects were partially attributed to an increased expression of endothelial NO synthase eNOS and cyclooxygenase COX as a result of the training intervention
Aim of this trial is therefore to determine whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent
Aim of this trial is therefore to determine whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent
Detailed Description:
A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle
Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound
Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 15702 | None | None | None |