Ignite Creation Date:
2024-05-06 @ 3:20 AM
Last Modification Date:
2024-10-26 @ 11:32 AM
Study NCT ID:
NCT02267785
Status:
UNKNOWN
Last Update Posted:
2019-05-31
First Post:
2014-10-14
Brief Title:
Exercise Targeting Cognitive Impairment in Parkinsons Disease
Sponsor:
University of Southern California
Organization:
University of Southern California
Study Overview
Official Title:
Exercise Targeting Cognitive Impairment in Parkinsons Disease
Status:
UNKNOWN
Status Verified Date:
2019-05
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this application is to compare and elucidate the effects of skill-based versus aerobic exercise versus control on mild cognitive impairment MCI of the executive function EF subtype in Parkinsons disease PD we hypothesize that skill-based exercise will result in the greatest improvement in EF and lead to modification of underlying neural substrates
Detailed Description:
Mild cognitive impairment MCI particularly of the executive function EF subtype is common in Parkinsons disease PD and transitions to dementia increased fall risk and poor quality of life EF is a set of processes that include mental flexibility and attention that are needed to learn and optimize performance of complex cognitive and motor skills Such skills include the ability to generalize task performance under different conditions context processing and to perform two tasks simultaneously termed dual-task DT performance Deficits in EF lead to problems in daily functioning and loss of independence and create psychosocial and economic burdens on patients and caregivers and stakeholders including health care providers There is currently no effective treatment in PD to address EF deficits Our animal and clinical studies in PD demonstrate that skilled exercise facilitates neuroplasticity of the basal ganglia BG a brain region sub-serving EF and supports the hypothesis that exercise will reverse EF deficits in PD Furthermore recent studies in healthy aging support that skill-based exercise that specifically promotes motor skill fitness MSF compared with aerobic exercise that promotes cardiovascular fitness CF has a greater impact on EF and related BG circuits The aim of this application is to compare and elucidate the effects of skill-based versus aerobic exercise versus control on MCI of the EF subtype in PD we hypothesize that skill-based exercise will result in the greatest improvement in EF and lead to modification of underlying neural substrates
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None