Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173563
Status:
UNKNOWN
Last Update Posted:
2007-12-03
First Post:
2005-09-12
Brief Title:
Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children
Status:
UNKNOWN
Status Verified Date:
2005-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Severe acute respiratory syndrome SARS is a new emerging infectious disease Its pathogen is a newly discovered coronavirus SARS-CoV The clinical course can be classified to 3 stages viral replication phase hyperimmune reactive phase and pulmonary destruction phase Human monocyte plays a critical role in the initiation of immune response in defending the intracellular pathogens eg viruses Monocytes can engulf viruses and present the viral antigens in the major histocompatibility MHC molecule to the cell surface to initiate T lymphocyte response Monocytes also secrete various cytokines to modulate immune response SARS-CoV is a mutant of animal virus to cause human disease and is able to cause unusual severe respiratory illness It is suggested the unusual severe disease is due to the intense immune reaction
The investigators will harvest human monocytes from healthy adult and children blood donors Monocytes would be cultured and infected by SARS-CoV The change of viral load is monitored after infection Cytokines secreted by monocytes after infection are also measured The difference of monocyte cytokine secretion is compared between adults and children The study is to verify the SARS-CoV infectivity of human monocytes and prove the unusual severity caused by SARS-CoV is related to viral-induced dysregulation of cytokine responses The results may also clarify why adults tend to have a more severe illness compared with children
The investigators will harvest human monocytes from healthy adult and children blood donors Monocytes would be cultured and infected by SARS-CoV The change of viral load is monitored after infection Cytokines secreted by monocytes after infection are also measured The difference of monocyte cytokine secretion is compared between adults and children The study is to verify the SARS-CoV infectivity of human monocytes and prove the unusual severity caused by SARS-CoV is related to viral-induced dysregulation of cytokine responses The results may also clarify why adults tend to have a more severe illness compared with children
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NSC92-2751-B-002-026-Y | None | None | None |