Ignite Creation Date:
2024-05-05 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00172562
Status:
UNKNOWN
Last Update Posted:
2006-03-01
First Post:
2005-09-12
Brief Title:
Bone Marrow Angiogenesis in Acute Myeloid Leukemia - Evaluated by Dynamic Contrast Enhanced Magnetic Resonance MR Image
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In malignant or neoplastic disease angiogenesis is defined as the generation of new capillaries from preexisting blood vessels eg by sprouting or by intusseption Through the pioneering work of Folkman it was recognized that angiogenesis plays an important role in tumor development progression and metastasis It is also conceivable that there are forms or developmental stages of leukemia multiple myeloma or lymphomas that will progress independently of angiogenesis Synthesis of angiogenesis activators such as vascular endothelial growth factor VEGF and other angiogenic factors such as basic fibroblast growth factor bFGF has been demonstrated for leukemia cells non-Hodgkins lymphoma and myeloma cells Microvessel density is also significantly elevated over normal controls with progressive increases according to the stages of myelodysplastic syndrome Increased microvessel density MVD in the bone marrow was found in patients with multiple myeloma in comparison to normal controls and increased MVD is an adverse prognostic marker in multiple myeloma However the functional status of the blood vessel eg permeability cannot be determined by the above mentioned methods
Detailed Description:
In malignant or neoplastic disease angiogenesis is defined as the generation of new capillaries from preexisting blood vessels eg by sprouting or by intusseption Through the pioneering work of Folkman it was recognized that angiogenesis plays an important role in tumor development progression and metastasis It is also conceivable that there are forms or developmental stages of leukemia multiple myeloma or lymphomas that will progress independently of angiogenesis Synthesis of angiogenesis activators such as vascular endothelial growth factor VEGF and other angiogenic factors such as basic fibroblast growth factor bFGF has been demonstrated for leukemia cells non-Hodgkins lymphoma and myeloma cells Microvessel density is also significantly elevated over normal controls with progressive increases according to the stages of myelodysplastic syndrome Increased microvessel density MVD in the bone marrow was found in patients with multiple myeloma in comparison to normal controls and increased MVD is an adverse prognostic marker in multiple myeloma However the functional status of the blood vessel eg permeability cannot be determined by the above mentioned methods
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None