Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00176384
Status:
COMPLETED
Last Update Posted:
2007-08-01
First Post:
2005-09-10
Brief Title:
Impact of Exercise Training on Exercise Capacity in Patients With Severe Chronic Heart Failure
Sponsor:
University of Leipzig
Organization:
University of Leipzig
Study Overview
Official Title:
Impact of Three Months of Aerobic Exercise Training on Exercise Capacity and Peripheral Maladaptations in Patients With Severe Chronic Heart Failure NYHA III b
Status:
COMPLETED
Status Verified Date:
2007-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with heart failure are limited in their exercise capacity due to skeletal muscle alteration and an impairment of peripheral perfusion Regular physical exercise training has been shown to partially correct these peripheral maladaptations in patients with stable heart failure which was associated with an improvement in exercise capacity However it is unknown so far whether regular physical activity also exerts beneficial effects in patients with severe chronic heart failure
Aim of the trial is therefore to assess the effects of aerobic exercise training on exercise capacity muscle maladaptations and peripheral perfusion in patients with severe chronic heart failure according to NYHA class III b
Aim of the trial is therefore to assess the effects of aerobic exercise training on exercise capacity muscle maladaptations and peripheral perfusion in patients with severe chronic heart failure according to NYHA class III b
Detailed Description:
A total of 36 patients with severe chronic heart failure are prospectively randomized to either 3 months of aerobic ergometer training or a sedentary control group
Before and after the intervention period maximal exercise capacity is assessed by ergospirometry endothelial function is determined by high-resolution A-mode ultrasound and muscle mass is determined by CT Skeletal muscle biopsies are obtained at begin and after 3 months and are analyzed for markers of muscle catabolismanabolism
Before and after the intervention period maximal exercise capacity is assessed by ergospirometry endothelial function is determined by high-resolution A-mode ultrasound and muscle mass is determined by CT Skeletal muscle biopsies are obtained at begin and after 3 months and are analyzed for markers of muscle catabolismanabolism
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None