Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173485
Status:
UNKNOWN
Last Update Posted:
2005-11-24
First Post:
2005-09-12
Brief Title:
The Study of Infection and Cell Inflammation in Peritoneal Dialysate
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A progressive decline of plasma triggering receptor expressed on myeloid cells-1 TREM-1 concentration indicates a favorable clinical evolution during the recovery phase of sepsis The expression of TREM-1 in dialysate of peritoneal dialysis patients was not yet documented We will collect the dialysate of peritonitis in peritoenal dialysis patients and analyze the time serial change
Detailed Description:
The triggering receptor expressed on myeloid cells-1 TREM-1 is a member of the immunoglobulin superfamily and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi 1 Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1 Conversely TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders In addition TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia During sepsis a progressive decline of plasma sTREM-1 concentration indicates a favorable clinical evolution during the recovery phase of sepsis In addition baseline sTREM-1 level may prove useful in predicting outcome of septic patients We will collect the dialysate of peritonitis in peritoneal dialysis patients and analyze the time serials change
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None