Ignite Creation Date:
2024-05-06 @ 3:14 AM
Last Modification Date:
2024-10-26 @ 11:30 AM
Study NCT ID:
NCT02237781
Status:
UNKNOWN
Last Update Posted:
2014-09-11
First Post:
2014-09-09
Brief Title:
Levels of Anti-Mullerian Hormone AMH During Ovarian Stimulation With Gonadotropins
Sponsor:
University of Athens
Organization:
University of Athens
Study Overview
Official Title:
Prospective Randomized Trial on the Level of Anti-Mullerian Hormone AMH in Women Undergoing Controlled Ovarian Stimulation for IVFwith Gonadotropins
Status:
UNKNOWN
Status Verified Date:
2014-09
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Anti-Mullerian Hormone AMH is produced only in small ovarian follicles with quite stable levels during the cycle There is not yet sufficient data to inform couples undergoing IVF about the effect of ovarian stimulation on the levels of AMH due to the increasing size of follicles and chances of success of the method
Detailed Description:
Patients undergoing IVF will be included in the study All patients will be counseled regarding their prognosis Anti-Mullerian Hormone AMH will be measured prior to the initiation of IVF and during ovarian stimulation Patients will be stimulated with a short GnRH-antagonist protocol All women will have measurements of serum FSH and estradiol E2 and a pelvic sonogram on the second day of their cycle Ovarian stimulation will be initiated with of gonadotropins either in the form of a combination of highly purified urinary FSH and LH or with a combination of Rec FSH and Rec LH The dose of gonadotropins will depend on the levels of estradiol and FSH prior stimulation All patients will be re-evaluated on day 3 and 5 of the stimulation measurment of AMH E2 and pelvic sonogram and dosage adjustments will be made and the antagonists Cetrorelix or ganirelix 025 mgday will be initiated on day 5 Measurment of AMH E2 and pelvic sonogram to conferm the size of follicles will be continue every second day untill the oocyte retrieval When at least 2 follicles reach an average diameter of 17 mm final oocyte maturation will be triggered with 10000IU of hCG Pregnyl Organon Greece Inc Oocyte retrieval will be performed 34 to 36 hours later Patients with successful fertilization will have embryo transfer under sonographic guidance on day 3 after retrieval
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None