Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173420
Status:
UNKNOWN
Last Update Posted:
2007-10-23
First Post:
2005-09-12
Brief Title:
Mechanisms of Neuropathic Pain Investigation by Contact Heat Evoked Potential
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Mechanisms of Neuropathic Pain Investigation by Contact Heat Evoked Potential
Status:
UNKNOWN
Status Verified Date:
2005-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In order to clarify the normal components of thermal and painful evoked potentials by heat in normal subjects of both genders and different age group to clarify the effect of specific anatomy in pain transduction transmission and modification and to establish the effect of peripheral nerve and their terminal free ending on the nociceptive transduction the investigators will use heat stimulation on normal controls and patients with neurological diseases to clarify such issues
Detailed Description:
Only a few studies focus on clinical diseases like neuropathic pain or neurogenic pain Little is known about the differences between normal and pathogenic pain processing It is an opportunity to apply EEG ERPs in the clinical fields In many clinical conditions brain lesions provide a chance to study the possible roles of one neural structure in pain integration and processing In addition the applications of EEGERPs on clinical conditions may be help in the understanding about mechanism and genesis of pain in pathogenic conditions the diagnosis of pathogenic pain and the therapeutic aspects of these abnormal pain senses
One limit in the study of human pain is the inappropriate stimulation method Evoked potentials by contact heat have previously been difficult to elicit due to slow temperature rise times associated with thermal stimulators However recently the CHEPS Contact Heat-Evoked Potential Stimulator is developed which uses a newly developed heat-foil technology and can create a rapid heating rate up to 70Csec The baseline and peak temperature and the rising time can be precisely controlled It provides a non-invasive technique in the investigation of human pain activation related to thermal and nociceptive pathways involved in pain processing Unlike the heat stimulation delivered by laser CHEPS can deliver noxious thermal stimuli repeatedly to a large area of skin to evoke a pain response of A-Delta and C fibers In addition the rate of stimulation can be rapid to lead to the effect of temporal summation When used with an EEG recording system a patients responses to pain perception and evoked potentials EPs can be recorded which provide objective information about integrity of the nociceptive afferents of peripheral nerve system spinal cord as well as the brain response of different structures The CHEPS provide the investigators a practical and convenient tool in clinical application to study pain The investigators will use the CHEPS as stimulation for studying the heat evoked potentials and analyze the difference between the normal subjects and patients with peripheral nerve diseases These might help to clarify the mechanism of neuropathic pain
One limit in the study of human pain is the inappropriate stimulation method Evoked potentials by contact heat have previously been difficult to elicit due to slow temperature rise times associated with thermal stimulators However recently the CHEPS Contact Heat-Evoked Potential Stimulator is developed which uses a newly developed heat-foil technology and can create a rapid heating rate up to 70Csec The baseline and peak temperature and the rising time can be precisely controlled It provides a non-invasive technique in the investigation of human pain activation related to thermal and nociceptive pathways involved in pain processing Unlike the heat stimulation delivered by laser CHEPS can deliver noxious thermal stimuli repeatedly to a large area of skin to evoke a pain response of A-Delta and C fibers In addition the rate of stimulation can be rapid to lead to the effect of temporal summation When used with an EEG recording system a patients responses to pain perception and evoked potentials EPs can be recorded which provide objective information about integrity of the nociceptive afferents of peripheral nerve system spinal cord as well as the brain response of different structures The CHEPS provide the investigators a practical and convenient tool in clinical application to study pain The investigators will use the CHEPS as stimulation for studying the heat evoked potentials and analyze the difference between the normal subjects and patients with peripheral nerve diseases These might help to clarify the mechanism of neuropathic pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None