Ignite Creation Date:
2024-05-06 @ 3:13 AM
Last Modification Date:
2024-10-26 @ 11:30 AM
Study NCT ID:
NCT02237378
Status:
TERMINATED
Last Update Posted:
2018-08-31
First Post:
2014-08-29
Brief Title:
A Pilot Study Evaluating Heart and Lung Metabolism in Pulmonary Hypertension Associated With Left Heart Disease
Sponsor:
Ottawa Heart Institute Research Corporation
Organization:
Ottawa Heart Institute Research Corporation
Study Overview
Official Title:
Evaluation of Cardiopulmonary Metabolism and Pulmonary Vascular Remodeling in Pulmonary Hypertension Associated With Left Heart Disease
Status:
TERMINATED
Status Verified Date:
2018-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Poor enrolment
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Right ventricular RV failure is the leading cause of death in pulmonary arterial hypertension PAH Right ventricular ejection fraction is one of the most important predictors of prognosis in heart failure patients regardless of cause It is estimated that 30-50 of patients with heart failure and preserved ejection fraction HFpEF have right ventricular dysfunction and up to 70 of these patients will have significant pulmonary hypertension PH both of which are related to much worse prognosis Right ventricular failure is becoming an increasingly prevalent and significant cause of morbidity in patients with left heart disease Despite the significance of RV function to survival there are no therapies available that directly or selectively improve RV function
The overall theme of this research project is to evaluate the mechanisms that contribute to the cause of right heart failure This small study is designed to look at the role of heart and lung metabolism and pulmonary hypertension as they relate to the development of right heart failure in cardiovascular diseasePH-LHD
The overall theme of this research project is to evaluate the mechanisms that contribute to the cause of right heart failure This small study is designed to look at the role of heart and lung metabolism and pulmonary hypertension as they relate to the development of right heart failure in cardiovascular diseasePH-LHD
Detailed Description:
The hemodynamic definition of PH-LHD involves a mean pulmonary artery pressure mPAP 25mm Hg at rest and pulmonary capillary wedge pressure PCWP of 15The coexistence of mitral insufficiency is also a characteristic of PH-LHD HFpEF is a condition caused by impaired relaxation of a stiffened myocardium as a consequence of an increased load to the left ventricle due to elevated systemic pressures
Pulmonary hemodynamics can be used to classify PH LHD as either passive or reactive irrespective of LV function It has been suggested that diastolic pressure gradient DPG may offer added prognostic value as a more accurate indicator of pulmonary vascular remodeling
Pulmonary hemodynamics can be used to classify PH LHD as either passive or reactive irrespective of LV function It has been suggested that diastolic pressure gradient DPG may offer added prognostic value as a more accurate indicator of pulmonary vascular remodeling
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None