Ignite Creation Date:
2024-05-06 @ 3:13 AM
Last Modification Date:
2024-10-26 @ 11:30 AM
Study NCT ID:
NCT02237053
Status:
COMPLETED
Last Update Posted:
2018-04-26
First Post:
2014-09-04
Brief Title:
Effects of Glucagon Administration on Energy Expenditure
Sponsor:
AdventHealth Translational Research Institute
Organization:
AdventHealth Translational Research Institute
Study Overview
Official Title:
A Prospective Randomized Placebo Saline-Controlled Balanced 3-treatment Regimen Crossover Study Comparing the Effects of Prolonged 13 h Hyperglucagonemia With Those of Acute 3 hr Hyperglucagonemia on Energy Expenditure and Endogenous Glucose Protection EGP
Status:
COMPLETED
Status Verified Date:
2018-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GLEE
Brief Summary:
The purpose of this study is to collect data to help researchers better understand the effects of glucagon on the amount of calories burned
Detailed Description:
1 To compare the effect of prolonged hyperglucagonemia to that of acute hyperglucagonemia on energy expenditure in healthy subjects using room indirect calorimetry in the setting of octreotide-mediated prevention of plasma insulin excursions
2 To compare the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on EGP in healthy subjects in the setting of octreotide-mediated prevention of plasma insulin excursions
3 To determine the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on rates of substrate oxidation fibroblast growth factor21 and metabolites of interest
2 To compare the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on EGP in healthy subjects in the setting of octreotide-mediated prevention of plasma insulin excursions
3 To determine the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on rates of substrate oxidation fibroblast growth factor21 and metabolites of interest
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None