Ignite Creation Date:
2024-05-06 @ 3:12 AM
Last Modification Date:
2024-10-26 @ 11:30 AM
Study NCT ID:
NCT02237716
Status:
UNKNOWN
Last Update Posted:
2014-09-11
First Post:
2014-08-26
Brief Title:
Rapid Intravenous Infusion of Mannitol Results in a Dipper-type Change in Stroke Volume Variation in Patients Undergoing Major Neurosurgery
Sponsor:
First Affiliated Hospital Sun Yat-Sen University
Organization:
First Affiliated Hospital Sun Yat-Sen University
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2014-09
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to observe the variation of Hemodynamicslactic acidbase excessperipheral vascular resistance and DO2 through FloTracVigileo system after rapid infusion mannitol in neurosurgeryThe hemodynamic changes after mannitol infusion are shown in Figure 1 HR Fig 1A and systolic BP Figure 1B significantly increased between 0 min and 10 min P 0041 and between -10 min and 10 min P 0073 respectively these two variables decreased steadily and returned to the baseline Diastolic BP Fig 1B showed no significant change after mannitol infusion P 0102 CVP Fig 1C significantly increased between -20 min and 0 min P 0001 and constantly decreased after 0 min which remained below the baseline between 30 min and 60 min CI Fig 1D and SVI Fig 1E showed a significant persistent increase between -20 min to 0 min P 0001 and between -20 min and 10 min P 0001 respectively SVV exhibited a dipper-type change shown as a significant decrease between -20 min and 0 min and a significant increase between 0 min and 60 min P 0001 which returned to the baseline after 20 min
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None