Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173953
Status:
COMPLETED
Last Update Posted:
2005-09-15
First Post:
2005-09-12
Brief Title:
Lymphocytic Subsets and Cytokine Production With H Pylori Infection
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Lymphocytic Subsets and Cytokine Production in the Gastric Samples of Patients With Helicobacter Pylori Infection
Status:
COMPLETED
Status Verified Date:
2000-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aims of this study are 1 to determine the cytokines produced by both Th1 and Th2 subsets in gastric antral biopsy specimens from Taiwanese patients before and after anti H pylori therapy 2 to obtain a detailed phenotypic characterization and distribution pattern of mucosal lymphocytes in H pylori-associated gastritis and to define possible contributing immune mechanisms responsible for the chronicity of the disease and its associated lesions
Detailed Description:
Helicobacter pylori a Gram-negative spiral bacterium has been first isolated from a patient with chronic active gastritis since 1982 Recent studies strongly suggest that chronic infection with H pylori is tightly associated with chronic gastritis peptic ulcer and gastric carcinoma However only a minority of infected people develop signs and symptoms of gastric pathology Thus both host and microbial factors may lead to different outcomes of infection In spite of high prevalence in general population and increasing clinical attention has been paid on this infection the knowledge of pathogenic mechanism of H pylori infection is still limited and little is known about the role of host immune response in the pathogenesis of diseaseThe aims of this study are 1 to determine the cytokines produced by both Th1 and Th2 subsets in gastric antral biopsy specimens from Taiwanese patients before and after anti H pylori therapy 2 to obtain a detailed phenotypic characterization and distribution pattern of mucosal lymphocytes in H pylori-associated gastritis and to define possible contributing immune mechanisms responsible for the chronicity of the disease and its associated lesions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 90M010 | None | None | None |