Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00173342
Status:
UNKNOWN
Last Update Posted:
2005-09-15
First Post:
2005-09-12
Brief Title:
Congenital or Idiopathic Complete Right Bundle Branch Block Physiological Significance and Molecular Characterization
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Congenital or Idiopathic Complete Right Bundle Branch Block Physiological Significance and Molecular Characterization
Status:
UNKNOWN
Status Verified Date:
2005-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is to determine 1 the incidence of altered right bundle conduction including CRBBB IRBBB or rsR pattern in the Taipei city based on the school survey databank from 1999 to 2002 2 the associated cardiac lesions 3 clinical presentations relevant to the altered right bundle conduction 4 the association with QTc prolongation and dispersion and HRV from a 5-minutes recording Finally molecular characterization for those with CRBBB or Brugada pattern EKG especially those with positive family history will be studied
Detailed Description:
The EKG pattern and medical records from the school survey from 1999 to 2002 in Taipei city will be reviewed and the basic data of those with CRBBB IRBBB and rsR pattern will be recorded Interview will be made and the echocardiographic measurements will be performed to identify associated cardiac defects EKG parameters and QT QTc QT dispersion QTc dispersion and HRV parameters will be obtained from a semi-automated system Time domain and frequency domain measures will be calculated and expressed as SDNN triangular index SDNN index total power low frequency power and high frequency power Mutational analysis and DNA sequencing will be conducted in those with CRBBB or Brugada pattern EKG especially those with positive family history
Based on these data the clinical significance of altered bundle branch conduction identified from a school survey may be defined For those with isolated CRBBB or IRBBB the adjunctive value of HRV and QT parameters will determined the high risk group and 24 hour Holter recording and Treadmill exercise test will then perform in these patients to define association with ventricular arrhythmia
Based on these data the clinical significance of altered bundle branch conduction identified from a school survey may be defined For those with isolated CRBBB or IRBBB the adjunctive value of HRV and QT parameters will determined the high risk group and 24 hour Holter recording and Treadmill exercise test will then perform in these patients to define association with ventricular arrhythmia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None