Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00166972
Status:
COMPLETED
Last Update Posted:
2005-09-14
First Post:
2005-09-12
Brief Title:
Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis
Status:
COMPLETED
Status Verified Date:
2005-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our study established a model combine the in silico biology and empirical methods to identify clinically useful biomarker from information of microarray gene expression profiles in public domain Through this method we found trophinin as a novel prognostic marker for early stage lung cancer which provide insight towards the process of cancer metastasis and the potential target for treatment
Detailed Description:
This study was to combine the in silico biology and empirical methods to identify clinically useful biomarker of lung cancer from microarray gene expression profiles in public database
Using the expression profile of a known metastasis suppressor CRMP-1 as a template to search for and compare transcriptome expressions in publicly accessible microarray datasets trophinin TRO was identified as the best correlated gene The expression pattern of trophinin in a lung cancer cell lines of invasion model was investigated using quantitative RT-PCR The role of trophinin in cancer metastasis was investigated by measuring the change of invasion activity in trophinin gene-transfected cell lines The relationship of trophinin and the clinicopathological characteristics of lung cancer were further examined by immunohistochemical staining
Using the expression profile of a known metastasis suppressor CRMP-1 as a template to search for and compare transcriptome expressions in publicly accessible microarray datasets trophinin TRO was identified as the best correlated gene The expression pattern of trophinin in a lung cancer cell lines of invasion model was investigated using quantitative RT-PCR The role of trophinin in cancer metastasis was investigated by measuring the change of invasion activity in trophinin gene-transfected cell lines The relationship of trophinin and the clinicopathological characteristics of lung cancer were further examined by immunohistochemical staining
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None