Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00169845
Status:
COMPLETED
Last Update Posted:
2018-03-14
First Post:
2005-09-09
Brief Title:
Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
Sponsor:
Laval University
Organization:
Laval University
Study Overview
Official Title:
Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
Status:
COMPLETED
Status Verified Date:
2018-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Epidemiologic studies suggest that low dietary intakes and low plasma concentrations of antioxidant vitamins and minerals are associated with increased risks of cancer especially for epidermoid tumors Patients with stage I or II head and neck cancer have a good prognosis with a 5-year relative survival of 60 to 90 depending of the tumor site However the benefit of treatment is often compromised by the occurrence of second primary cancers which develop in 20 of patients during the first 5 years after diagnosis We conducted a randomized chemoprevention trial among patients with head and neck cancer treated by radiation therapy to determine whether supplementation combining two antioxidants alpha-tocopherol and beta-carotene could reduce the incidence of second primary cancers in this patient population primary objective of the trial This study was conducted with funds from the NCIC 008176004738013211 and was completed
In this cohort of head and neck cancer patients we evaluated whether nine potential prognostic serum markers measured at the time of diagnosis were related to recurrence occurence of second primary cancers and survival This study was conducted with funds from the NCIC 018100 and was completed
Presently we evaluate genetic polymorphismsGWAS associated with prognosis NCIC grant 019502 We also assess the relationship between vitamin D dietary intake serum level and genetic polymorphisms of key vitamin D-related genes and head and neck long-term outcomes NCI grant 1R03CA141615-01
In this cohort of head and neck cancer patients we evaluated whether nine potential prognostic serum markers measured at the time of diagnosis were related to recurrence occurence of second primary cancers and survival This study was conducted with funds from the NCIC 018100 and was completed
Presently we evaluate genetic polymorphismsGWAS associated with prognosis NCIC grant 019502 We also assess the relationship between vitamin D dietary intake serum level and genetic polymorphisms of key vitamin D-related genes and head and neck long-term outcomes NCI grant 1R03CA141615-01
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 018100 | OTHER_GRANT | National Cancer Institute of Canada | httpsreporternihgovquickSearch1R03CA141615-01 |
| NCIC-4738 | OTHER_GRANT | None | None |
| NCIC-8176 | OTHER_GRANT | None | None |
| NCIC-13211 | OTHER_GRANT | None | None |
| NCIC-019502 | OTHER_GRANT | None | None |
| 1R03CA141615-01 | NIH | None | None |